To provide precision medicine for better cancer care, researchers must work on clinical
patient data, such as electronic medical records, physiological measurements, biochemistry …

The enormous growth in the amount of data generated by the life sciences is continuously
shifting the field from model-driven science towards data-driven science. The need for …

Genome sequences of individuals constitute sensitive data and must be safeguarded from
unauthorized access or disclosure. While encryption of human genome sequences at rest …

Sequencing data quality control can significantly prevent low-quality data from impacting
downstream applications in bioinformatics. The enormous growth of biological sequencing …

This paper outlines the technical and organizational measures implemented by the Italian
supercomputing center, CINECA, to efficiently collect, process, and store sensitive-omics …

Assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq)
generates genome-wide chromatin accessibility profiles, providing valuable insights into …

Next-generation sequencing (NGS) has taken on major importance in clinical oncology
practice. With the advent of targeted therapies capable of effectively targeting specific …

High-throughput sequencing and hardware-accelerated computing have both developed
tremendously within the last decade. In genomics, progress is fueled by new technologies …

Rapid advances in high‐throughput DNA sequencing technologies have enabled large‐
scale whole genome sequencing (WGS) studies. Before performing association analysis …

Variant calling is a fundamental task that involves identifying variants in an individual's
genome compared to the reference genome. Knowing these variants is critical for assessing …