[HTML][HTML] Epigenetic modulations in triple-negative breast cancer: Therapeutic implications for tumor microenvironment

L Zhou, CW Yu - Pharmacological research, 2024 - Elsevier
Triple-negative breast cancer (TNBC) is an aggressive subtype lacking estrogen receptors,
progesterone receptors and lacks HER2 overexpression. This absence of critical molecular …

Advances in targeted therapy of breast cancer with antibody-drug conjugate

MA Subhan, VP Torchilin - Pharmaceutics, 2023 - mdpi.com
Antibody–drug conjugates (ADCs) are a potential and promising therapy for a wide variety of
cancers, including breast cancer. ADC-based drugs represent a rapidly growing field of …

Natural compounds, optimal combination of brusatol and polydatin promote anti-tumor effect in breast cancer by targeting Nrf2 signaling pathway

J Li, J Zhang, Y Zhu, LO Afolabi, L Chen… - International Journal of …, 2023 - mdpi.com
Triple-negative breast cancer (TNBC) has been clearly recognized as a heterogeneous
tumor with the worst prognosis among the subtypes of breast cancer (BC). The advent and …

Disclosing a metabolic signature of cisplatin resistance in MDA-MB-231 triple-negative breast cancer cells by NMR metabolomics

TJ Carneiro, ALMB Carvalho, M Vojtek, IF Carmo… - Cancer Cell …, 2023 - Springer
This work compared the metabolic profile of a parental MDA-MB-231 cisplatin-sensitive
triple negative breast cancer (TNBC) cell line with that of a derived cisplatin-resistant line, to …

Repurposing proteasome inhibitors for improved treatment of triple-negative breast cancer

P Larsson, D Pettersson, M Olsson… - Cell Death …, 2024 - nature.com
Triple-negative breast cancer (TNBC) is associated with poor prognosis and limited
treatment options due to the lack of important receptors (estrogen receptor [ER] …

[HTML][HTML] Polydatin: A natural compound with multifaceted anticancer properties

K Imtiyaz, M Shafi, KU Fakhri, L Uroog, B Zeya… - Journal of Traditional …, 2024 - Elsevier
Cancer poses a significant global health challenge, contributing to substantial mortality rates
and driving the urgent need for exploration into bioactive compounds with potent anticancer …

Sacituzumab govitecan and radiotherapy in metastatic, triple-negative, and BRCA-mutant breast cancer patient with active brain metastases: a case report

P di Mauro, G Schivardi, R Pedersini, L Laini… - Frontiers in …, 2023 - frontiersin.org
Background Triple-negative breast cancer (TNBC) is an aggressive cancer subtype, owing
to its high metastatic potential: Patients who develop brain metastases (BMs) have a poor …

New biomarkers and treatment advances in triple-negative breast cancer

B El Hejjioui, S Lamrabet, S Amrani Joutei, N Senhaji… - Diagnostics, 2023 - mdpi.com
Triple-negative breast cancer (TNBC) is a specific subtype of breast cancer lacking hormone
receptor expression and HER2 gene amplification. TNBC represents a heterogeneous …

Combination of ionizing radiation and 2-thio-6-azauridine induces cell death in radioresistant triple negative breast cancer cells by downregulating CD151 expression

R Marni, M Malla, A Chakraborty, MK Voonna… - Cancer Chemotherapy …, 2024 - Springer
Background Triple-negative breast cancer (TNBC) represents the most aggressive subtype
of breast cancer and is frequently resistant to therapy, ultimately resulting in treatment …

Towards agility in breast cancer treatment principles as adopted from agile software engineering

Y Odeh, M Al-Balas - Journal of Multidisciplinary Healthcare, 2024 - Taylor & Francis
Purpose The complex nature of breast cancer demands flexible and adaptable principles
that can account for the diverse characteristics and evolving conditions of each patient …