Pangenome graphs can represent all variation between multiple reference genomes, but
current approaches to build them exclude complex sequences or are based upon a single …

The history of yeast Saccharomyces cerevisiae, aka brewer's or baker's yeast, is intertwined
with our own. Initially domesticated 8,000 years ago to provide sustenance to our ancestors …

Loss of heterozygosity (LOH) is a mitotic recombination event that converts heterozygous
loci to homozygous loci. This mutation event is widespread in organisms that have asexual …

Recent advancements in genomics, propelled by artificial intelligence, have unlocked
unprecedented capabilities in interpreting genomic sequences, mitigating the need for …

Current temporal studies of DNA replication are either low-resolution or require complex cell
synchronisation and/or sorting procedures. Here we introduce Nanotiming, a single …

Eukaryotic genomes are folded into DNA loops mediated by structural maintenance of
chromosomes (SMC) complexes such as cohesin, condensin, and Smc5/6. This …

Telomere shortening ultimately causes replicative senescence. However, identifying the
mechanisms driving replicative senescence in cell populations is challenging due to the …

Fruiting body development in macrofungi is an intensive research subject. In this study, high-
quality genomes were assembled for two sexually compatible monokaryons from a …

As a unicellular eukaryote, the budding yeast Saccharomyces cerevisiae strikes a unique
balance between biological complexity and experimental tractability, serving as a long …

Gene expression varies between individuals and corresponds to a key step linking
genotypes to phenotypes. However, our knowledge regarding the species-wide genetic …