Mechanisms controlling cellular and systemic iron homeostasis
In mammals, hundreds of proteins use iron in a multitude of cellular functions, including vital
processes such as mitochondrial respiration, gene regulation and DNA synthesis or repair …
processes such as mitochondrial respiration, gene regulation and DNA synthesis or repair …
Normal and dysregulated crosstalk between iron metabolism and erythropoiesis
Erythroblasts possess unique characteristics as they undergo differentiation from
hematopoietic stem cells. During terminal erythropoiesis, these cells incorporate large …
hematopoietic stem cells. During terminal erythropoiesis, these cells incorporate large …
Universal cell embeddings: A foundation model for cell biology
Develo** a universal representation of cells which encompasses the tremendous
molecular diversity of cell types within the human body and more generally, across species …
molecular diversity of cell types within the human body and more generally, across species …
scGRN: a comprehensive single-cell gene regulatory network platform of human and mouse
X Huang, C Song, G Zhang, Y Li, Y Zhao… - Nucleic Acids …, 2024 - academic.oup.com
Gene regulatory networks (GRNs) are interpretable graph models encompassing the
regulatory interactions between transcription factors (TFs) and their downstream target …
regulatory interactions between transcription factors (TFs) and their downstream target …
Current advances in modulating tumor hypoxia for enhanced therapeutic efficacy
Z Liu, X Liu, W Zhang, R Gao, H Wei, CY Yu - Acta Biomaterialia, 2024 - Elsevier
Hypoxia is a common feature of most solid tumors, which promotes the proliferation,
invasion, metastasis, and therapeutic resistance of tumors. Researchers have been …
invasion, metastasis, and therapeutic resistance of tumors. Researchers have been …
Hypoxia and renal fibrosis
Renal fibrosis is the final stage of most progressive kidney diseases. Chronic kidney disease
(CKD) is associated with high comorbidity and mortality. Thus, preventing fibrosis and …
(CKD) is associated with high comorbidity and mortality. Thus, preventing fibrosis and …
Targeting Endoplasmic Reticulum Stress by Natural and Chemical Compounds Ameliorates Cisplatin-Induced Nephrotoxicity: A Review
Cisplatin is a chemotherapeutic that dose-dependently causes renal complications such as
decreased kidney function and acute kidney injury. The endoplasmic reticulum (ER) is …
decreased kidney function and acute kidney injury. The endoplasmic reticulum (ER) is …
Crosstalk between oxygen signaling and iron metabolism in renal interstitial fibroblasts
N Suzuki, Y Iwamura, K Kato, H Ishioka… - Journal of Clinical …, 2024 - pmc.ncbi.nlm.nih.gov
To maintain the oxygen supply, the production of red blood cells (erythrocytes) is promoted
under low-oxygen conditions (hypoxia). Oxygen is carried by hemoglobin in erythrocytes, in …
under low-oxygen conditions (hypoxia). Oxygen is carried by hemoglobin in erythrocytes, in …
Insoluble HIFa protein aggregates by cadmium disrupt hypoxia-prolyl hydroxylase (PHD)-hypoxia inducible factor (HIFa) signaling in renal epithelial (NRK-52E) and …
The kidney is the main organ that senses changes in systemic O2 pressure by hypoxia-PHD-
HIFa (HPH) signaling, resulting in adaptive target gene activation, including erythropoietin …
HIFa (HPH) signaling, resulting in adaptive target gene activation, including erythropoietin …
Defining the molecular fingerprint of bladder and kidney fibroblasts
Fibroblasts are integral to the organization and function of all organs and play critical roles in
pathologies such as fibrosis; however, we have limited understanding of the fibroblasts that …
pathologies such as fibrosis; however, we have limited understanding of the fibroblasts that …