The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

Cells' local mechanical environment can be as important in guiding cellular responses as
many well-characterized biochemical cues. Hydrogels that mimic the native extracellular …

Chimeric antigen receptor (CAR) therapy has had a transformative effect on the treatment of
haematologic malignancies,,,,–, but it has shown limited efficacy against solid tumours. Solid …

Extracellular vesicles (EVs) are biological nanoparticles that promote intercellular
communication by delivering bioactive cargo over short and long distances. Short-distance …

Spatial transcriptomics (ST) methods unlock molecular mechanisms underlying tissue
development, homeostasis, or disease. However, there is a need for easy-to-use, high …

Alterations in extracellular matrix (ECM) architecture and stiffness represent hallmarks of
cancer. Whether the biomechanical property of ECM impacts the functionality of tumor …

Disease progression is usually accompanied by changes in the biochemical composition of
cells and tissues and their biophysical properties. For instance, hallmarks of cancer include …

The killing function of cytotoxic T cells can be enhanced biochemically. Here we show that
blocking the mechanical sensor PIEZO1 in T cells strengthens their traction forces and …

Tumor cells movement and migration are inseparable from the integrity of lipid rafts and the
formation of lamellipodia, and lipid rafts are also a prerequisite for the formation of …

The metabolic reprogramming of glioblastoma (GBM) poses a tremendous obstacle to
effective immunotherapy due to its impact on the immunosuppressive microenvironment. In …