Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …

The current terminology in frontotemporal dementia (FTD) uses specific terms to differentiate
the clinical syndromic presentation from the underlying molecular pathology. Although FTD …

Mutations in the human progranulin (GRN) gene are a leading cause of frontotemporal lobar
degeneration (FTLD). While previous studies implicate aberrant microglial activation as a …

Functional brain connectivity of the resting-state networks has gained recent attention as a
possible biomarker of Alzheimer's Disease (AD). In this paper, we review the literature of …

Heterozygous loss-of-function mutations in progranulin (GRN) cause frontotemporal
dementia (FTD), a leading cause of early-onset dementia characterized clinically by …

The study of pollutant effects is extremely important to address the epochal challenges we
are facing, where world populations are increasingly moving from rural to urban centers …

Objective Progranulin-related frontotemporal dementia (FTD-GRN) is a fast progressive
disease. Modelling the cascade of multimodal biomarker changes aids in understanding the …

Background Frontotemporal dementia (FTD) phenotypes are classically associated with
distinctive cortical atrophy patterns and regional hypometabolism. However, the spectrum of …

Presymptomatic studies in ALS have consistently captured considerable disease burden
long before symptom manifestation and contributed important academic insights. With the …

Introduction Neurodegenerative diseases can be considered as 'disconnection
syndromes,'in which a communication breakdown prompts cognitive or motor dysfunction …