Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

Stem cell therapy is widely recognized as a promising strategy for exerting therapeutic
effects after injury in degenerative diseases. However, limitations such as low cell retention …

Background Dystrophic epidermolysis bullosa is a rare genetic blistering skin disease
caused by mutations in COL7A1, which encodes type VII collagen (C7). Beremagene …

Undesired on-and off-target effects of CRISPR-Cas nucleases remain a challenge in
genome editing. While the use of Cas9 nickases has been shown to minimize off-target …

Dystrophic epidermolysis bullosa (DEB) is one of the major types of EB, a rare hereditary
group of trauma-induced blistering skin disorders. DEB is caused by inherited pathogenic …

Integrins are heterodimeric glycoproteins crucial to the physiology and pathology of many
biological functions. As adhesion molecules, they mediate immune cell trafficking, migration …

Patients with inflammatory bowel disease (IBD) often have other immune-mediated
inflammatory diseases (IMIDs), and the prevalence of any IMID is higher in IBD patients than …

Existing approaches to therapeutic gene transfer are marred by the transient nature of gene
expression following non-integrative gene delivery and by safety concerns due to the …

Collagens provide the building blocks for diverse tissues and organs. Furthermore, these
proteins act as signaling molecules that control cell behavior during organ development …

Background Epidermolysis bullosa (EB) is a rare genetic disorder manifesting with skin and
mucosal membrane blistering in different degrees of severity. Objective Epidemiological …