Pathology has always been fueled by technological advances. Histology powered the study
of tissue architecture at single-cell resolution and remains a cornerstone of clinical …

The proximal part of the small intestine, including duodenum and jejunum, is not only
dedicated to nutrient digestion and absorption but is also a highly regulated immune site …

Tissues are exposed to diverse inflammatory challenges that shape future inflammatory
responses. While cellular metabolism regulates immune function, how metabolism programs …

Single-cell decisions made in complex environments underlie many bacterial phenomena.
Image-based transcriptomics approaches offer an avenue to study such behaviors, yet these …

Single-cell RNA sequencing (scRNA-seq) has advanced our understanding of cell types
and their heterogeneity within the human liver, but the spatial organization at single-cell …

Sarcoidosis is an inflammatory disease characterized by immune cell–rich granulomas that
form in multiple organs. In this issue of the JCI, Sati and colleagues used scRNA-seq and …

While spatial transcriptomics has undeniably revolutionized our ability to study cellular
organization, it has driven the development of a great number of innovative transcriptomics …

Tissues are exposed to diverse inflammatory challenges that shape future inflammatory
responses. While cellular metabolism regulates immune function, how metabolism programs …

Inflammatory bowel disease (IBD) is an umbrella term for two conditions (Crohn's Disease
and Ulcerative Colitis) that is characterized by chronic inflammation of the gastrointestinal …

Interrogation of host–microbe interactions has long been a source of both basic discoveries
and benefits to human health. Here, we review the role that functional genomics approaches …