Sex and gender: modifiers of health, disease, and medicine

F Mauvais-Jarvis, NB Merz, PJ Barnes, RD Brinton… - The Lancet, 2020 - thelancet.com
Clinicians can encounter sex and gender disparities in diagnostic and therapeutic
responses. These disparities are noted in epidemiology, pathophysiology, clinical …

Burkitt lymphoma

C López, B Burkhardt, JKC Chan, L Leoncini… - Nature Reviews …, 2022 - nature.com
Burkitt lymphoma (BL) is an aggressive form of B cell lymphoma that can affect children and
adults. The study of BL led to the identification of the first recurrent chromosomal aberration …

Gene regulation in time and space during X-chromosome inactivation

A Loda, S Collombet, E Heard - Nature Reviews Molecular Cell Biology, 2022 - nature.com
X-chromosome inactivation (XCI) is the epigenetic mechanism that ensures X-linked dosage
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for …

Androgen conspires with the CD8+ T cell exhaustion program and contributes to sex bias in cancer

H Kwon, JM Schafer, NJ Song, S Kaneko, A Li… - Science …, 2022 - science.org
Sex bias exists in the development and progression of nonreproductive organ cancers, but
the underlying mechanisms are enigmatic. Studies so far have focused largely on sexual …

Sex disparities matter in cancer development and therapy

S Haupt, F Caramia, SL Klein, JB Rubin… - Nature Reviews …, 2021 - nature.com
Curing cancer through precision medicine is the paramount aim of the new wave of
molecular and genomic therapies. Currently, whether patients with non-reproductive …