Cerebral cortical structural alteration patterns across four major psychiatric disorders in 5549 individuals

J Matsumoto, M Fukunaga, K Miura, K Nemoto… - Molecular …, 2023 - nature.com
According to the operational diagnostic criteria, psychiatric disorders such as schizophrenia
(SZ), bipolar disorder (BD), major depressive disorder (MDD), and autism spectrum disorder …

Advances in the knowledge and therapeutics of schizophrenia, major depression disorder, and bipolar disorder from human brain organoid research

R Villanueva - Frontiers in Psychiatry, 2023 - frontiersin.org
Tridimensional cultures of human induced pluripotent cells (iPSCs) experimentally directed
to neural differentiation, termed “brain organoids” are now employed as an in vitro assay that …

[HTML][HTML] Convergence of brain transcriptomic and neuroimaging patterns in schizophrenia, bipolar disorder, autism spectrum disorder, and major depressive disorder

DJ Ardesch, I Libedinsky, LH Scholtens, Y Wei… - Biological Psychiatry …, 2023 - Elsevier
Background Psychiatric conditions show overlap in their symptoms, genetics, and
involvement in brain areas and circuits. Structural alterations in the brain have been found to …

Advanced nano engineering of surface-enhanced Raman scattering technologies for sensing applications

VA Tran, TTV Tran, VD Doan, GNL Vo, VH Tran… - Applied Materials …, 2024 - Elsevier
Surface-enhanced Raman scattering has attracted a lot of attention as a very effective
analytical method in the field of biosensors. The method makes use of the enhanced signal …

A phylogenetically-conserved axis of thalamocortical connectivity in the human brain

S Oldham, G Ball - Nature Communications, 2023 - nature.com
The thalamus enables key sensory, motor, emotive, and cognitive processes via
connections to the cortex. These projection patterns are traditionally considered to originate …

Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study

F Georgiadis, S Larivière, D Glahn, LE Hong… - Molecular …, 2024 - nature.com
Schizophrenia is a prototypical network disorder with widespread brain-morphological
alterations, yet it remains unclear whether these distributed alterations robustly reflect the …

[HTML][HTML] Neuroimaging and biosample collection in the Toronto Adolescent and Youth Cohort Study: Rationale, methods, and early data

EW Dickie, SH Ameis, I Boileau, AO Diaconescu… - Biological Psychiatry …, 2024 - Elsevier
Abstract Background The Toronto Adolescent and Youth (TAY) Cohort Study will
characterize the neurobiological trajectories of psychosis spectrum symptoms, functioning …

Proof-of-concept recall-by-genotype study of extremely low and high Alzheimer's polygenic risk reveals autobiographical deficits and cingulate cortex correlates

T Lancaster, B Creese, V Escott-Price, I Driver… - Alzheimer's Research & …, 2023 - Springer
Background Genome-wide association studies demonstrate that Alzheimer's disease (AD)
has a highly polygenic architecture, where thousands of independent genetic variants …

Multimodal map** of regional brain vulnerability to focal cortical dysplasia

HM Lee, SJ Hong, R Gill, B Caldairou, I Wang, J Zhang… - Brain, 2023 - academic.oup.com
Focal cortical dysplasia (FCD) type II is a highly epileptogenic developmental malformation
and a common cause of surgically treated drug-resistant epilepsy. While clinical …

Abnormal structural‒functional coupling patterning in progressive supranuclear palsy is associated with diverse gradients and histological features

J Qu, R Zhu, Y Wu, G Xu, D Wang - Communications Biology, 2024 - nature.com
The anatomy of the brain supports inherent processes, fostering mental abilities and
eventually facilitating adaptive behavior. Recent studies have shown that progressive …