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Preoperative chemotherapy, radiotherapy and surgical decision-making in patients with borderline resectable and locally advanced pancreatic cancer
TF Stoop, RT Theijse, LWF Seelen… - Nature Reviews …, 2024 - nature.com
Surgical resection combined with systemic chemotherapy is the cornerstone of treatment for
patients with localized pancreatic cancer. Upfront surgery is considered suboptimal in cases …
patients with localized pancreatic cancer. Upfront surgery is considered suboptimal in cases …
[HTML][HTML] Early detection of pancreatic cancer: opportunities and challenges
Most patients with pancreatic ductal adenocarcinoma (PDAC) present with symptomatic,
surgically unresectable disease. Although the goal of early detection of PDAC is laudable …
surgically unresectable disease. Although the goal of early detection of PDAC is laudable …
Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia
JE Rupert, A Narasimhan, DHA Jengelley… - Journal of Experimental …, 2021 - rupress.org
Most patients with pancreatic adenocarcinoma (PDAC) suffer cachexia; some do not. To
model heterogeneity, we used patient-derived orthotopic xenografts. These phenocopied …
model heterogeneity, we used patient-derived orthotopic xenografts. These phenocopied …
Effects of weight loss and sarcopenia on response to chemotherapy, quality of life, and survival
It has frequently been shown that patients with cancer are one of the largest hospital patient
groups with a prevalence for malnutrition. Weight loss is a frequent manifestation of …
groups with a prevalence for malnutrition. Weight loss is a frequent manifestation of …
Nutritional support and therapy in pancreatic surgery: a position paper of the International Study Group on Pancreatic Surgery (ISGPS)
Background The optimal nutritional therapy in the field of pancreatic surgery is still debated.
Methods An international panel of recognized pancreatic surgeons and pancreatologists …
Methods An international panel of recognized pancreatic surgeons and pancreatologists …
Sarcopenia and obesity
M Zamboni, S Rubele, AP Rossi - Current Opinion in Clinical …, 2019 - journals.lww.com
Further research is needed to compare different definitions of sarcopenic/dynapenic obesity
to clarify the relationship between obesity and the most important adverse outcomes in the …
to clarify the relationship between obesity and the most important adverse outcomes in the …
Immunonutrition and prehabilitation in pancreatic cancer surgery: A new concept in the era of ERAS® and neoadjuvant treatment
Pancreatic cancer (PC) is an aggressive disease, with a growing incidence, and a poor
prognosis. Neoadjuvant treatments in PC are highly recommended in borderline resectable …
prognosis. Neoadjuvant treatments in PC are highly recommended in borderline resectable …
Chemotherapy-induced sarcopenia
F Bozzetti - Current treatment options in oncology, 2020 - Springer
Opinion statement Sarcopenia is being consistently recognized as a condition not only
associated with the presence of a malignancy but also induced by the oncologic therapies …
associated with the presence of a malignancy but also induced by the oncologic therapies …
Prehabilitation prior to surgery for pancreatic cancer: a systematic review
JR Bundred, SK Kamarajah, JS Hammond, CH Wilson… - Pancreatology, 2020 - Elsevier
Introduction Prehabilitation aims to improve fitness and outcomes of patients undergoing
major surgery. This systematic review aimed to appraise current available evidence …
major surgery. This systematic review aimed to appraise current available evidence …
Preservation of muscle mass as a strategy to reduce the toxic effects of cancer chemotherapy on body composition
Muscle wasting often occurs as a consequence of anticancer treatments and is indicative of
worse outcomes and poor quality of life in cancer patients. Accurate assessment of body …
worse outcomes and poor quality of life in cancer patients. Accurate assessment of body …