Exosomes─ nature's lipid nanoparticles, a rising star in drug delivery and diagnostics

R Tenchov, JM Sasso, X Wang, WS Liaw, CA Chen… - ACS …, 2022 - ACS Publications
Exosomes are a subgroup of nanosized extracellular vesicles enclosed by a lipid bilayer
membrane and secreted by most eukaryotic cells. They represent a route of intercellular …

Extracellular vesicles in kidney disease

C Grange, B Bussolati - Nature Reviews Nephrology, 2022 - nature.com
Extracellular vesicles are released by the majority of cell types and circulate in body fluids.
They function as a long-distance cell-to-cell communication mechanism that modulates the …

Review of the isolation, characterization, biological function, and multifarious therapeutic approaches of exosomes

S Gurunathan, MH Kang, M Jeyaraj, M Qasim, JH Kim - Cells, 2019 - mdpi.com
Exosomes are extracellular vesicles that contain a specific composition of proteins, lipids,
RNA, and DNA. They are derived from endocytic membranes and can transfer signals to …

Potential use of exosomes as diagnostic biomarkers and in targeted drug delivery: progress in clinical and preclinical applications

MN Huda, M Nafiujjaman, IG Deaguero… - ACS biomaterials …, 2021 - ACS Publications
Exosomes are cell-derived vesicles containing heterogeneous active biomolecules such as
proteins, lipids, mRNAs, receptors, immune regulatory molecules, and nucleic acids. They …

Exosomes: biogenesis, biologic function and clinical potential

Y Zhang, Y Liu, H Liu, WH Tang - Cell & bioscience, 2019 - Springer
Exosomes are nano-sized biovesicles released into surrounding body fluids upon fusion of
multivesicular bodies and the plasma membrane. They were shown to carry cell-specific …

Biomarkers in stress related diseases/disorders: diagnostic, prognostic, and therapeutic values

K Dhama, SK Latheef, M Dadar, HA Samad… - Frontiers in molecular …, 2019 - frontiersin.org
Various internal and external factors negatively affect the homeostatic equilibrium of
organisms at the molecular to the whole-body level, inducing the so-called state of stress …

Recent advances in models, mechanisms, biomarkers, and interventions in cisplatin-induced acute kidney injury

SJ Holditch, CN Brown, AM Lombardi… - International journal of …, 2019 - mdpi.com
Cisplatin is a widely used chemotherapeutic agent used to treat solid tumours, such as
ovarian, head and neck, and testicular germ cell. A known complication of cisplatin …

Isolation and characterization of urinary extracellular vesicles: implications for biomarker discovery

ML Merchant, IM Rood, JKJ Deegens… - Nature Reviews …, 2017 - nature.com
Urine is a valuable diagnostic medium and, with the discovery of urinary extracellular
vesicles, is viewed as a dynamic bioactive fluid. Extracellular vesicles are lipid-enclosed …

Exosomes and microvesicles in normal physiology, pathophysiology, and renal diseases

A Ståhl, K Johansson, M Mossberg, R Kahn… - Pediatric …, 2019 - Springer
Extracellular vesicles are cell-derived membrane particles ranging from 30 to 5,000 nm in
size, including exosomes, microvesicles, and apoptotic bodies. They are released under …

Exosomes: novel biomarkers for clinical diagnosis

J Lin, J Li, B Huang, J Liu, X Chen… - The scientific world …, 2015 - Wiley Online Library
Exosomes are 30–120 nm endocytic membrane‐derived vesicles that participate in cell‐to‐
cell communication and protein and RNA delivery. Exosomes harbor a variety of proteins …