ABSTRACT Introduction Lipophilic efficiency (LipE) and lipophilic metabolic efficiency
(LipMetE) are valuable tools that can be utilized as part of a multiparameter optimization …

Among the deadliest diseases, cancer is characterized by tumors or an increased number of
a specific type of cell because of uncontrolled divisions during mitosis. Researchers in the …

Acute myelogenous leukemia (AML), a heterogeneous disease of the blood and bone
marrow, is characterized by the inability of myeloblasts to differentiate into mature cell types …

We used a structure-based drug discovery approach to identify novel inhibitors of human
dihydroorotate dehydrogenase (DHODH), which is a therapeutic target for treating cancer …

Several human diseases are caused by enteroviruses and are currently clinically
untreatable, pushing the research to identify new antivirals. A notable number of benzo [d][1 …

Patients with relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL) have a poor
prognosis with few therapeutic options. With the goal of identifying novel therapeutic targets …

Dihydroorotate dehydrogenase (DHODH) is a mitochondrial enzyme that affects many
aspects essential to cell proliferation and survival. Recently, DHODH has been identified as …

Macrocyclic molecules have emerged as significant contenders in drug development and
supramolecular chemistry. Paritaprevir is a 15-membered macrocycle approved for the …

The realm of drug development and supramolecular chemistry has been revolutionized by
the emergence of macrocyclic compounds, which have emerged as formidable contenders …

DHODH inhibition represents an attractive approach to overcome differentiation blockade for
the treatment of AML. In a previous communication, we described our efforts leading to the …