T cells are an important component of adaptive immunity and protect the host from infectious
diseases and cancers. However, uncontrolled T cell immunity may cause autoimmune …

Steady-state hematopoietic stem cells'(HSCs) self-renewal and differentiation toward their
mature progeny in the adult bone marrow is tightly regulated by cues from the …

T memory stem (TSCM) cells are a rare subset of memory lymphocytes endowed with the
stem cell–like ability to self-renew and the multipotent capacity to reconstitute the entire …

Infections induce pathogen-specific T cell differentiation into diverse effectors (Teff) that give
rise to memory (Tmem) subsets. The cell-fate decisions and lineage relationships that …

Inflammatory bowel disease (IBD) encompasses a spectrum of gastrointestinal disorders
driven by dysregulated immune responses against gut microbiota. We integrated single-cell …

Purpose Interleukin-15 (IL-15) has significant potential in cancer immunotherapy as an
activator of antitumor CD8 T and natural killer (NK) cells. The primary objectives of this trial …

In metazoans, specific tasks are relegated to dedicated organs that are established early in
development, occupy discrete locations and typically remain fixed in size. The adult immune …

Advancing our understanding of mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumor development, organ transplantation, and chronic infections …

Upon stimulation with their cognate antigen, naive T cells undergo proliferation and
differentiation into effector cells, followed by apoptosis or survival as precursors of long‐lived …

Memory T cells are critical for long-term immunity against reinfection and require interleukin-
7 (IL-7), but the mechanisms by which IL-7 controls memory T cell survival, particularly …