Abstract Calcium (Ca2+) is among the most important intracellular messengers in living
organisms. Understanding the players and dynamics of Ca2+ signalling pathways in plants …

Membrane contact sites between organelles are essential for maintaining cellular
homeostasis, which requires the continuous exchange of signaling molecules, ions …

Parkin, an E3 ubiquitin ligase and a Parkinson's disease (PD) related gene, translocates to
impaired mitochondria and drives their elimination via autophagy, a process known as …

Contact sites are discrete areas of organelle proximity that coordinate essential
physiological processes across membranes, including Ca2+ signaling, lipid biosynthesis …

Mitochondrial and lysosomal activities are crucial to maintain cellular homeostasis: optimal
coordination is achieved at their membrane contact sites where distinct protein machineries …

Abstract Coronavirus disease (COVID-19) is a contagious respiratory disease caused by the
SARS-CoV-2 virus. The clinical phenotypes are variable, ranging from spontaneous …

Intracellular neurofibrillary tangles (NFT) composed by tau and extracellular amyloid beta
(Aβ) plaques accumulate in Alzheimer's disease (AD) and contribute to neuronal …

Plants activate an immune or symbiotic response depending on the detection of distinct
signals from root-interacting microbes. Both signalling cascades involve Ca2+ as a central …

Wnt signaling affects fundamental development pathways and, if aberrantly activated,
promotes the development of cancers. Wnt signaling is modulated by different factors, but …

Chloroplasts are integral to sensing biotic and abiotic stress in plants, but their role in
transducing Ca2+-mediated stress signals remains poorly understood,. Here we identify …