Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction

A Colson, P Sonveaux, F Debiève… - Human reproduction …, 2021 - academic.oup.com
BACKGROUND The placenta is the functional interface between the mother and the fetus
during pregnancy, and a critical determinant of fetal growth and life-long health. In the first …

16th international congress on antiphospholipid antibodies task force report on antiphospholipid syndrome treatment trends

H Cohen, MJ Cuadrado, D Erkan, A Duarte-Garcia… - Lupus, 2020 - journals.sagepub.com
Antiphospholipid syndrome (APS), an acquired autoimmune thrombophilia, is characterised
by thrombosis and/or pregnancy morbidity in association with persistent antiphospholipid …

[HTML][HTML] FIGO (international Federation of Gynecology and obstetrics) initiative on fetal growth: best practice advice for screening, diagnosis, and management of fetal …

N Melamed, A Baschat, Y Yinon… - … of Gynaecology and …, 2021 - ncbi.nlm.nih.gov
Fetal growth restriction (FGR) is defined as the failure of the fetus to meet its growth potential
due to a pathological factor, most commonly placental dysfunction. Worldwide, FGR is a …

Pravastatin versus placebo in pregnancies at high risk of term preeclampsia

M Döbert, AN Varouxaki, AC Mu, A Syngelaki… - Circulation, 2021 - Am Heart Assoc
Background: Effective screening for term preeclampsia is provided by a combination of
maternal factors with measurements of mean arterial pressure, serum placental growth …

Prevention of preeclampsia

M Ma'ayeh, MM Costantine - Seminars in Fetal and Neonatal Medicine, 2020 - Elsevier
Preeclampsia is an obstetric disorder that affects 3–8% of pregnant women and remains a
leading cause of short-and long-term neonatal and maternal morbidity and mortality …

Pravastatin, proton-pump inhibitors, metformin, micronutrients, and biologics: new horizons for the prevention or treatment of preeclampsia

S Tong, J Tu'uhevaha, R Hastie, F Brownfoot… - American journal of …, 2022 - Elsevier
There has been increasing research momentum to identify new therapeutic agents for the
prevention or treatment of preeclampsia, drugs that can affect the underlying disease …

A randomized pilot clinical trial of pravastatin versus placebo in pregnant patients at high risk of preeclampsia

MM Costantine, H West, KL Wisner, S Caritis… - American journal of …, 2021 - Elsevier
Background Preeclampsia remains a major cause of maternal and neonatal morbidity and
mortality. Biologic plausibility, compelling preliminary data, and a pilot clinical trial support …

[HTML][HTML] Preeclampsia: linking placental ischemia with maternal endothelial and vascular dysfunction

BA Bakrania, FT Spradley, HA Drummond… - Comprehensive …, 2020 - ncbi.nlm.nih.gov
Preeclampsia (PE), a hypertensive disorder, occurs in 3% to 8% of pregnancies in the
United States and affects over 200,000 women and newborns per year. The United States …

The role of statins in the prevention of preeclampsia

DD Smith, MM Costantine - American journal of obstetrics and gynecology, 2022 - Elsevier
Preeclampsia is a common hypertensive disorder of pregnancy associated with
considerable neonatal and maternal morbidities and mortalities. However, the exact cause …

Animal models of preeclampsia: causes, consequences, and interventions

KL Gatford, PH Andraweera, CT Roberts, AS Care - Hypertension, 2020 - Am Heart Assoc
Preeclampsia is a common pregnancy complication, affecting 2% to 8% of pregnancies
worldwide, and is an important cause of both maternal and fetal morbidity and mortality …