Transcription factor EB (TFEB), a member of the MiT/TFE family of basic helix-loop-helix
leucine zipper transcription factors, is an established central regulator of the …

Transcription factor EB (TFEB) is considered the master transcriptional regulator of
autophagy and lysosomal biogenesis, which regulates target gene expression through …

The MiT‐TFE family of basic helix‐loop‐helix leucine‐zipper transcription factors includes
four members: TFEB, TFE 3, TFEC, and MITF. Originally described as oncogenes, these …

During starvation the transcriptional activation of catabolic processes is induced by the
nuclear translocation and consequent activation of transcription factor EB (TFEB), a master …

In Parkinson's disease (PD) there is a selective degeneration of neuromelanin-containing
neurons, especially substantia nigra dopaminergic neurons. In humans, neuromelanin …

Macro (Autophagy) is a catabolic process that relies on the cooperative function of two
organelles: the lysosome and the autophagosome. The recent discovery of a transcriptional …

Neurodegenerative diseases characterized by aberrant accumulation of undigested cellular
components represent unmet medical conditions for which the identification of actionable …

The lysosome has long been viewed as the recycling center of the cell. However, recent
discoveries have challenged this simple view and have established a central role of the …

The autophagy–lysosomal pathway (ALP) is involved in the degradation of long-lived
proteins. Deficits in the ALP result in protein aggregation, the generation of toxic protein …

The discovery of a gene network regulating lysosomal biogenesis and its transcriptional
regulator transcription factor EB (TFEB) revealed that cells monitor lysosomal function and …