The vacuolar (H+)-ATPases (V-ATPases) are ATP-dependent proton pumps that acidify
intracellular compartments and are also present at the plasma membrane. They function in …

Cryo-electron microscopy (cryo-EM) can now be used to determine high-resolution structural
information on a diverse range of biological specimens. Recent advances have been driven …

Pharmacological inhibition of vacuolar-type H+-ATPase (V-ATPase) by its specific inhibitor
can abrogate tumor metastasis, prevent autophagy, and reduce cellular signaling …

Transmission electron microscopy (EM) is a versatile technique that can be used to image
biological specimens ranging from intact eukaryotic cells to individual proteins> 150 kDa …

Despite the great progress recently made in resolving their structures, investigation of the
structural biology of membrane proteins still presents major challenges. Even with new …

V-ATPase is the dominant proton pump in plant cells. It contributes to cytosolic pH
homeostasis and energizes transport processes across endomembranes of the secretory …

The increasing resistance to currently available insecticides in the malaria vector,
Anopheles mosquitoes, hampers their use as an effective vector control strategy for the …

Intracellular pathogenic bacteria evade the immune response by replicating within host
cells. Legionella pneumophila, the causative agent of Legionnaires' Disease, makes use of …

Pulse crops produced for direct human consumption (dry bean, dry pea, lentil, and chickpea)
are an important source of protein and complex carbohydrates for millions living throughout …

Soybean seed basic 7S globulin (Bg7S)-like proteins are found in many plant species. Bg7S
was originally thought to be a major seed storage protein but was later found to be …