Objectives Designing studies with an internal pilot phase may optimise the use of pilot work
to inform more efficient randomised controlled trials (RCTs). Careful selection of preagreed …

Adaptive designs can make clinical trials more flexible by utilising results accumulating in
the trial to modify the trial's course in accordance with pre-specified rules. Trials with an …

OBJECTIVE: To illustrate controversial issues associated with stop** randomized
controlled trials (RCTs) early for apparent benefit. STUDY DESIGN AND SETTING: The …

High quality protocols facilitate proper conduct, reporting, and external review of clinical
trials. However, the completeness of trial protocols is often inadequate. To help improve the …

Background The preferred timing of umbilical-cord clam** in preterm infants is unclear.
Methods We randomly assigned fetuses from women who were expected to deliver before …

Background In women with late preterm pre-eclampsia, the optimal time to initiate delivery is
unclear because limitation of maternal disease progression needs to be balanced against …

Aim We assessed the management and outcomes of non-ST segment elevation myocardial
infarction (NSTEMI) patients randomly assigned to fractional flow reserve (FFR)-guided …

Background Infections acquired in hospital are an important cause of morbidity and mortality
in very preterm infants. Several small trials have suggested that supplementing the enteral …

Background Each year, worldwide about 530,000 women die from causes related to
pregnancy and childbirth. Of the deaths 99% are in low and middle income countries …

Background Women's groups and health education by peer counsellors can improve the
health of mothers and children. We assessed their effects on mortality and breastfeeding …