Characterizing protein-protein interactions with thermal proteome profiling
BC Searle - Current Opinion in Structural Biology, 2024 - Elsevier
Thermal proteome profiling (TPP) is an innovative technique that uses the principle of
protein thermal stability to identify potential protein interaction partners. Employing …
protein thermal stability to identify potential protein interaction partners. Employing …
AI-driven antibody design with generative diffusion models: current insights and future directions
Therapeutic antibodies are at the forefront of biotherapeutics, valued for their high target
specificity and binding affinity. Despite their potential, optimizing antibodies for superior …
specificity and binding affinity. Despite their potential, optimizing antibodies for superior …
[HTML][HTML] Integrating computational design and experimental approaches for next-generation biologics
A Son, J Park, W Kim, W Lee, Y Yoon, J Ji… - Biomolecules, 2024 - pmc.ncbi.nlm.nih.gov
Therapeutic protein engineering has revolutionized medicine by enabling the development
of highly specific and potent treatments for a wide range of diseases. This review examines …
of highly specific and potent treatments for a wide range of diseases. This review examines …
Introduction: Molecular Crowding
A Pastore, G Rivas Caballero, PA Temussi - Chemical Reviews, 2024 - ACS Publications
6697 https://doi. org/10.1021/acs. chemrev. 4c00287 Chem. Rev. 2024, 124, 6697− 6699
processes in high-viscosity environments, and several methods based on molecular …
processes in high-viscosity environments, and several methods based on molecular …
[HTML][HTML] Diffusion of proteins in crowded solutions studied by docking-based modeling
The diffusion of proteins is significantly affected by macromolecular crowding. Molecular
simulations accounting for protein interactions at atomic resolution are useful for …
simulations accounting for protein interactions at atomic resolution are useful for …
Pair-EGRET: enhancing the prediction of protein–protein interaction sites through graph attention networks and protein language models
Motivation Proteins are responsible for most biological functions, many of which require the
interaction of more than one protein molecule. However, accurately predicting protein …
interaction of more than one protein molecule. However, accurately predicting protein …
In Silico View of Crowding: Biomolecular Processes to Nanomaterial Design
It is widely accepted that deciphering biomolecular structure and function requires going
beyond the single-molecule or single-complex paradigm. The densely packed …
beyond the single-molecule or single-complex paradigm. The densely packed …
Recent progress in modeling and simulation of biomolecular crowding and condensation inside cells
A Mathur, R Ghosh, A Nunes-Alves - Journal of Chemical …, 2024 - ACS Publications
Macromolecular crowding in the cellular cytoplasm can potentially impact diffusion rates of
proteins, their intrinsic structural stability, binding of proteins to their corresponding partners …
proteins, their intrinsic structural stability, binding of proteins to their corresponding partners …
Transmembrane proteins in grape immunity: current knowledge and methodological advances
A Gallucci, D Giordano, A Facchiano… - Frontiers in Plant …, 2024 - frontiersin.org
Transmembrane proteins (TMPs) are pivotal components of plant defence mechanisms,
serving as essential mediators in the response to biotic stresses. These proteins are among …
serving as essential mediators in the response to biotic stresses. These proteins are among …
Pouring SIRAH on NAMD
J Cantero, A Ballesteros-Casallas… - The Journal of …, 2024 - ACS Publications
Molecular dynamics (MD) simulations provide an invaluable platform for exploring the
dynamics of complex biomolecular systems at atomic resolution. However, compatibility …
dynamics of complex biomolecular systems at atomic resolution. However, compatibility …