Ferroptosis is a kind of regulated cell death (RCD) caused by the redox state disorder of
intracellular microenvironment controlled by glutathione (GSH) peroxidase 4 (GPX4), which …

Abstract Alzheimer's disease (AD), one of the most common neurodegenerative diseases
worldwide, has a devastating personal, familial, and societal impact. In spite of profound …

Brain iron accumulation has been found to accelerate disease progression in amyloid-β (Aβ)
positive Alzheimer patients, though the mechanism is still unknown. Microglia have been …

Objective This paper is a proposal for an update of the iron hypothesis of Alzheimer's
disease (AD), based on large‐scale emerging evidence. Background Iron featured …

A growing body of evidence suggests that the dysregulation of neuronal iron may play a
critical role in Alzheimer's disease. Recent MRI studies have established a relationship …

A sensitive and accurate imaging technique capable of tracking the disease progression of
Alzheimer's Disease (AD) driven amnestic dementia would be beneficial. A currently …

Alzheimer's disease (AD), the most common type of dementia, is a neurodegenerative
disorder characterized by progressive cognitive dysfunction. Epidemiological investigation …

Research in ultrahigh magnetic field strength combined with ultrahigh and ultrafast gradient
technology has provided enormous gains in sensitivity, resolution, and contrast for …

Background Berberine (BBR) is a natural alkaloid extracted from the herb Coptis chinensis.
This compound has the ability to penetrate the blood-brain barrier (BBB) and exhibit …

No disease modifying drugs have been approved for Alzheimer's disease despite recent
major investments by industry and governments throughout the world. The burden of …