Early-onset colorectal cancer: initial clues and current views
Over the past several decades, the incidence of early-onset colorectal cancer (EOCRC; in
patients< 50 years old) has increased at an alarming rate. Although robust and scientifically …
patients< 50 years old) has increased at an alarming rate. Although robust and scientifically …
Inositols: from established knowledge to novel approaches
Myo-inositol (myo-Ins) and D-chiro-inositol (D-chiro-Ins) are natural compounds involved in
many biological pathways. Since the discovery of their involvement in endocrine signal …
many biological pathways. Since the discovery of their involvement in endocrine signal …
Biosynthesized gold nanoparticles that activate Toll-like receptors and elicit localized light-converting hyperthermia for pleiotropic tumor immunoregulation
H Qin, Y Chen, Z Wang, N Li, Q Sun, Y Lin… - Nature …, 2023 - nature.com
Manipulating the tumor immune contexture towards a more active state can result in better
therapeutic outcomes. Here we describe an easily accessible bacterial biomineralization …
therapeutic outcomes. Here we describe an easily accessible bacterial biomineralization …
CD36 mediates SARS-CoV-2-envelope-protein-induced platelet activation and thrombosis
Z Tang, Y Xu, Y Tan, H Shi, P **, Y Li, J Teng… - Nature …, 2023 - nature.com
Aberrant coagulation and thrombosis are associated with severe COVID-19 post-SARS-CoV-
2 infection, yet the underlying mechanism remains obscure. Here we show that serum levels …
2 infection, yet the underlying mechanism remains obscure. Here we show that serum levels …
Inhibitory effect of Dendrobium officinale polysaccharide on oxidative damage of glial cells in aging mice by regulating gut microbiota
L Xu, X Zeng, Y Liu, Z Wu, X Zheng, X Zhang - International Journal of …, 2023 - Elsevier
Polysaccharides extracted from Dendrobium officinale have various physiological effects. In
this study, we used D-galactose-induced senescent mice as an animal model to investigate …
this study, we used D-galactose-induced senescent mice as an animal model to investigate …
An updated overview of the emerging role of patch and film-based buccal delivery systems
Buccal mucosal membrane offers an attractive drug-delivery route to enhance both systemic
and local therapy. This review discusses the benefits and drawbacks of buccal drug delivery …
and local therapy. This review discusses the benefits and drawbacks of buccal drug delivery …
Cannabidiol alleviates neuroinflammation and attenuates neuropathic pain via targeting FKBP5
Microglia is a heterogeneous population that mediates neuroinflammation in the central
nervous system (CNS) and plays a crucial role in develo** neuropathic pain. FKBP5 …
nervous system (CNS) and plays a crucial role in develo** neuropathic pain. FKBP5 …
Clarithromycin solid lipid nanoparticles for topical ocular therapy: Optimization, evaluation, and in vivo studies
Solid lipid nanoparticles (SLNs) are being extensively exploited as topical ocular carrier
systems to enhance the bioavailability of drugs. This study investigated the prospects of drug …
systems to enhance the bioavailability of drugs. This study investigated the prospects of drug …
Papaverine: a miraculous alkaloid from opium and its multimedicinal application
The pharmacological actions of benzylisoquinoline alkaloids are quite substantial, and have
recently attracted much attention. One of the principle benzylisoquinoline alkaloids has been …
recently attracted much attention. One of the principle benzylisoquinoline alkaloids has been …
Nanoemulsion based vehicle for effective ocular delivery of moxifloxacin using experimental design and pharmacokinetic study in rabbits
Nanoemulsion is one of the potential drug delivery strategies used in topical ocular therapy.
The purpose of this study was to design and optimize a nanoemulsion-based system to …
The purpose of this study was to design and optimize a nanoemulsion-based system to …