Phenotypic features of cancer cachexia‐related loss of skeletal muscle mass and function: lessons from human and animal studies

A Martin, D Freyssenet - Journal of cachexia, sarcopenia and …, 2021 - Wiley Online Library
Cancer cachexia is a complex multi‐organ catabolic syndrome that reduces mobility,
increases fatigue, decreases the efficiency of therapeutic strategies, diminishes the quality of …

Metabolomics and its applications in cancer cachexia

P Cui, X Li, C Huang, Q Li, D Lin - Frontiers in molecular biosciences, 2022 - frontiersin.org
Cancer cachexia (CC) is a complicated metabolic derangement and muscle wasting
syndrome, affecting 50–80% cancer patients. So far, molecular mechanisms underlying CC …

Amiloride ameliorates muscle wasting in cancer cachexia through inhibiting tumor-derived exosome release

L Zhou, T Zhang, W Shao, R Lu, L Wang, H Liu, B Jiang… - Skeletal muscle, 2021 - Springer
Background Cancer cachexia (CAC) reduces patient survival and quality of life.
Developments of efficient therapeutic strategies are required for the CAC treatments. This …

Taurine protects C2C12 myoblasts from impaired cell proliferation and myotube differentiation under cisplatin-induced ROS exposure

L Zhou, R Lu, C Huang, D Lin - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
In cancer patients, chemotherapeutic medication induces aberrant ROS (reactive oxygen
species) accumulation in skeletal muscles, resulting in myofiber degradation, muscle …

Metabolic profiling of urinary chiral amino-containing biomarkers for gastric cancer using a sensitive chiral chlorine-labeled probe by HPLC-MS/MS

R Huang, K Shen, Q He, Y Hu, C Sun… - Journal of Proteome …, 2021 - ACS Publications
Screening of characteristic biomarkers from chiral amino-containing metabolites in
biological samples is difficult and important for the noninvasive diagnosis of gastric cancer …

Potential clinical applications of alpha‑ketoglutaric acid in diseases

X Meng, H Liu, L Peng, W He… - Molecular Medicine …, 2022 - spandidos-publications.com
As an intermediate of the tricarboxylic acid cycle, also known as 2‑oxoglutarate, α‑
ketoglutaric acid (AKG) plays an important role in maintaining physiological functions and …

Cancer cachexia: Focus on cachexia factors and inter-organ communication

Y Wang, Z Dong, Z An, W ** - Chinese Medical Journal, 2024 - journals.lww.com
Cancer cachexia is a multi-organ syndrome and closely related to changes in signal
communication between organs, which is mediated by cancer cachexia factors. Cancer …

Cellular and non-target metabolomics approaches to understand the antifungal activity of methylaervine against Fusarium solani

W Dan, J Gao, L Li, Y Xu, J Wang, J Dai - Bioorganic & Medicinal Chemistry …, 2021 - Elsevier
Botanical fungicides are promising replacements for pure chemical synthetic pesticides in
agriculture and organic food production. Methylaervine with good physicochemical …

Microbial-Related Metabolites May Be Involved in Eight Major Biological Processes and Represent Potential Diagnostic Markers in Gastric Cancer

S Nie, A Wang, X Chen, Y Gong, Y Yuan - Cancers, 2023 - mdpi.com
Simple Summary This article integrated analyses of the microbial and metabolic
characteristics of gastric cancer (GC), as well as their coexistence relationship, and …

Nuclear magnetic resonance-based metabolomic study of rat serum after anterior cruciate ligament injury

JT Li, N Zeng, ZP Yan, T Liao, X Chen, GX Ni - Scientific Reports, 2023 - nature.com
Anterior cruciate ligament (ACL) injury, a common sports injury, is associated with a high risk
of subsequent osteoarthritis (OA), which can cause serious pain and disability …