Glycosylation is the most abundant and complex protein modification, and can have a
profound structural and functional effect on the conjugate. The oligosaccharide fraction is …

Antibodies play a critical role in linking the adaptive immune response to the innate immune
system. In humans, antibodies are categorized into five classes, IgG, IgM, IgA, IgE, and IgD …

Approximately one-third of the world's population suffers from allergies. Exposure to
allergens crosslinks immunoglobulin E (IgE) antibodies that are bound to mast cells and …

Summary HLA class I (HLA-I) glycoproteins drive immune responses by presenting antigens
to cognate CD8+ T cells. This process is often hijacked by tumors and pathogens for …

The spike (S) glycoprotein in the envelope of SARS-CoV-2 is densely glycosylated but the
functions of its glycosylation are unknown. Here we demonstrate that S is recognized in a …

Immunoglobulin E (IgE) antibodies are well known for their role in mediating allergic
reactions, and their powerful effector functions activated through binding to Fc receptors …

Protein N-and O-glycosylation are well known co-and post-translational modifications of
immunoglobulins. Antibody glycosylation on the Fab and Fc portion is known to influence …

Glycans on proteins and lipids are known to alter with malignant transformation. The study of
these may contribute to the discovery of biomarkers and treatment targets as well as …

In-depth site-specific investigations of protein glycosylation are the basis for understanding
the biological function of glycoproteins. Mass spectrometry-based N-and O-glycopeptide …

Immunoglobulin ε (IgE) antibodies are the primary mediators of allergic diseases, which
affect more than 1 in 10 individuals worldwide. IgE specific for innocuous environmental …