There has been an upsurge in the number of clinical trials involving chemically modified
oligonucleotide-based drug candidates after the FDA approval of Vitravene, Macugen, and …

Nucleic acid based therapeutics have an allure for medicinal chemists due to their potential
for specific control of gene expression. Persistent efforts have resulted in the FDA approval …

While interactions between carbon monoxide (CO) and mitochondria have been previously
studied, the methods used to deliver CO (gas or CO-releasing metal carbonyl compounds) …

Oligonucleotide therapeutics, particularly antisense oligonucleotides (ASOs), have emerged
as promising candidates in drug discovery. However, their effective delivery to the target …

Nucleic acid chemistry is a huge research area that has received new impetus due to the
recent explosive success of oligonucleotide therapy. In order for an oligonucleotide to …

Their unique ability to selectively bind specific nucleic acid sequences makes
oligonucleotides promising bioactive agents. However, modifications of the nucleic acid …

Nine guanidinylated amphiphilic polycarbonates are rationally designed and synthesized.
Each polymer has the same biodegradable backbone but different side groups. The …

A number of alkyl, aryl and bifunctional isothiocyanates are obtained in moderate to high
yields (41–94%) in a two-step, one-pot reaction of the parent primary amines or their salts …

Nuclease resistant oligonucleotides with cell penetrating properties - Chemical Communications
(RSC Publishing) DOI:10.1039/C4CC08837A Royal Society of Chemistry View PDF …

Antisense oligonucleotides (ASOs) have the ability of binding to endogenous nucleic acid
targets, thereby inhibiting the gene expression. Although ASOs have great potential in the …