Discovery proteomics for COVID-19: where we are now

A McArdle, KE Washington… - Journal of proteome …, 2021 - ACS Publications
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible
coronavirus responsible for the pandemic coronavirus disease 2019 (COVID-19), which has …

The significance of antigen-antibody-binding avidity in clinical diagnosis

Y Li, HS Yang, PJ Klasse, Z Zhao - Critical Reviews in Clinical …, 2025 - Taylor & Francis
Immunoglobulin G (IgG) and immunoglobulin M (IgM) testing are commonly used to
determine infection status. Typically, the detection of IgM indicates an acute or recent …

Vaccination versus infection with SARS‐CoV‐2: Establishment of a high avidity IgG response versus incomplete avidity maturation

F Struck, P Schreiner, E Staschik… - Journal of Medical …, 2021 - Wiley Online Library
Avidity is defined as the binding strength of immunoglobulin G (IgG) toward its target
epitope. Avidity is directly related to affinity, as both processes are determined by the best fit …

BNT162b2 mRNA SARS-CoV-2 vaccine elicits high avidity and neutralizing antibodies in healthcare workers

F Pratesi, T Caruso, D Testa, T Tarpanelli, A Gentili… - Vaccines, 2021 - mdpi.com
The BNT162b2 vaccine, containing lipid nanoparticles-formulated mRNA encoding the full-
length spike protein of SARS-CoV-2, has been employed to immunize health care workers …

Poor neutralization and rapid decay of antibodies to SARS-CoV-2 variants in vaccinated dialysis patients

J Bassi, O Giannini, C Silacci-Fregni, L Pertusini… - PLoS …, 2022 - journals.plos.org
Patients on dialysis are at risk of severe course of SARS-CoV-2 infection. Understanding the
neutralizing activity and coverage of SARS-CoV-2 variants of vaccine-elicited antibodies is …

Experimental studies using OMV in a new platform of SARS-CoV-2 vaccines

EB Gaspar, CR Prudencio… - Human Vaccines & …, 2021 - Taylor & Francis
Although COVID-19 vaccines have recently been approved for emergency use, search for
new vaccines are still urgent, since the access of the countries, especially the poorest, to the …

Avidity of IgG to SARS-CoV-2 RBD as a prognostic factor for the severity of COVID-19 reinfection

V Manuylov, O Burgasova, O Borisova, S Smetanina… - Viruses, 2022 - mdpi.com
The avidity index (AI) of IgG to the RBD of SARS-CoV-2 was determined for 71 patients with
a mild (outpatient) course of COVID-19, including 39 primarily and 36 secondarily reinfected …

Binding and avidity signatures of polyclonal sera from individuals with different exposure histories to severe acute respiratory syndrome coronavirus 2 infection …

G Singh, A Abbad, J Tcheou, DR Mendu… - The Journal of …, 2023 - academic.oup.com
Background The number of exposures to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) and to vaccine antigens affect the magnitude and avidity of the polyclonal …

RBD and spike DNA-based immunization in rabbits elicited IgG avidity maturation and high neutralizing antibody responses against SARS-CoV-2

HHM da Costa, DJB Orts, AD Moura, AN Duarte-Neto… - Viruses, 2023 - mdpi.com
Neutralizing antibodies (nAbs) are a critical part of coronavirus disease 2019 (COVID-19)
research as they are used to gain insight into the immune response to severe acute …

COVID-19 vaccines based on viral nanoparticles displaying a conserved B-cell epitope show potent immunogenicity and a long-lasting antibody response

JF Affonso de Oliveira, Z Zhao, Y **ang… - Frontiers in …, 2023 - frontiersin.org
The COVID-19 pandemic caused by SARS-CoV-2 sparked intensive research into the
development of effective vaccines, 50 of which have been approved thus far, including the …