There are two types of electron bifurcation (EB), either quinone-or flavin-based
(QBEB/FBEB), that involve reduction of a quinone or flavin by a two-electron transfer and two …

Flavin-based electron bifurcation is a newly discovered mechanism, by which a hydride
electron pair from NAD (P) H, coenzyme F420H2, H2, or formate is split by flavoproteins into …

It has been proposed that early bacteria, or even the last universal common ancestor of all
cells, were thermophilic. However, research on the origin and evolution of thermophily is …

Currently one of the biggest challenges for society is to combat global warming. A solution to
this global threat is the implementation of a CO2-based bioeconomy and a H2-based …

Flavin-based electron bifurcation is a long hidden mechanism of energetic coupling present
mainly in anaerobic bacteria and archaea that suffer from energy limitations in their …

Ancestral metabolism has remained controversial due to a lack of evidence beyond
sequence-based reconstructions. Although prebiotic chemists have provided hints that …

Life on Earth is driven by electron transfer reactions catalyzed by a suite of enzymes that
comprise the superfamily of oxidoreductases (Enzyme Classification EC1). Most modern …

The discovery of a new energy-coupling mechanism termed flavin-based electron
bifurcation (FBEB) in 2008 revealed a novel field of application for flavins in biology. The key …

Geothermal environments, including terrestrial hot springs and deep-sea hydrothermal
sediments, often contain many poorly understood lineages of archaea. Here, we recovered …

Electron bifurcation plays a key role in anaerobic energy metabolism, but it is a relatively
new discovery, and only limited mechanistic information is available on the diverse enzymes …