Recent progress toward the discovery of small molecules as novel anti-respiratory syncytial virus agents
Respiratory syncytial virus (RSV) stands as the foremost cause of infant hospitalization
globally, ranking second only to malaria in terms of infant mortality. Although three vaccines …
globally, ranking second only to malaria in terms of infant mortality. Although three vaccines …
4′-Fluorouridine is an oral antiviral that blocks respiratory syncytial virus and SARS-CoV-2 replication
The COVID-19 pandemic has underscored the critical need for broad-spectrum therapeutics
against respiratory viruses. Respiratory syncytial virus (RSV) is a major threat to pediatric …
against respiratory viruses. Respiratory syncytial virus (RSV) is a major threat to pediatric …
Structures and mechanisms of nonsegmented, negative-strand RNA virus polymerases
The nonsegmented, negative-strand RNA viruses (nsNSVs), also known as the order
Mononegavirales, have a genome consisting of a single strand of negative-sense RNA …
Mononegavirales, have a genome consisting of a single strand of negative-sense RNA …
Ruthenium-catalyzed chemoselective N–H bond insertion reactions of 2-pyridones/7-azaindoles with sulfoxonium ylides
A ruthenium-catalyzed highly chemoselective N-alkylation of 2-pyridones has been
developed, affording N-alkylated 2-pyridone derivatives in good yields and excellent N …
developed, affording N-alkylated 2-pyridone derivatives in good yields and excellent N …
Anti-viral activity of thiazole derivatives: An updated patent review
Introduction Several viral infections cause life-threatening consequences in humans, making
them the most serious public health concerns. Despite the fact that several antiviral …
them the most serious public health concerns. Despite the fact that several antiviral …
Immunity cell responses to RSV and the role of antiviral inhibitors: a systematic review
G Churiso, G Husen, D Bulbula… - Infection and drug …, 2022 - Taylor & Francis
Antigen-presenting cells recognize respiratory syncytial virus antigens, and produce
cytokines and chemokines that act on immune cells. Dendritic cells play the main role in …
cytokines and chemokines that act on immune cells. Dendritic cells play the main role in …
Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases
VA Kleiner, T O. Fischmann, JA Howe… - Communications …, 2023 - nature.com
Respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) are related RNA
viruses responsible for severe respiratory infections and resulting disease in infants, elderly …
viruses responsible for severe respiratory infections and resulting disease in infants, elderly …
Antiviral activity of pyrimidine containing compounds: Patent review
Viruses are still the most prevalent infectious pathogens on a worldwide scale, with many of
them causing life-threatening illnesses in humans. Influenza viruses, because of their …
them causing life-threatening illnesses in humans. Influenza viruses, because of their …
Structural basis of paramyxo-and pneumovirus polymerase inhibition by non-nucleoside small-molecule antivirals
Small-molecule antivirals can be used as chemical probes to stabilize transitory
conformational stages of viral target proteins, facilitating structural analyses. Here, we …
conformational stages of viral target proteins, facilitating structural analyses. Here, we …
Orally efficacious lead of the AVG inhibitor series targeting a dynamic interface in the respiratory syncytial virus polymerase
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory infections in infants
and the immunocompromised, yet no efficient therapeutic exists. We have identified the AVG …
and the immunocompromised, yet no efficient therapeutic exists. We have identified the AVG …