Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait
or disease and may become a valuable tool for advancing precision medicine. However …

UK Biobank is a large-scale prospective study with deep phenoty** and genomic data. Its
open-access policy allows researchers worldwide, from academia or industry, to perform …

Background It is proposed that, through restriction to individuals delineated as high risk,
polygenic risk scores (PRSs) might enable more efficient targeting of existing cancer …

Background The multifactorial Breast and Ovarian Analysis of Disease Incidence and
Carrier Estimation Algorithm (BOADICEA) breast cancer risk prediction model has been …

Ovarian cancer is a complex disease, mostly observed in postmenopausal women, and is
associated with poor survival rates. It is the sixth most common cancer and the fifth most …

Lung cancer is the most common cause of cancer-related deaths globally. Although smoking-
related lung cancers continue to account for the majority of diagnoses, smoking rates have …

Cancer site–specific polygenic risk scores (PRS) effectively identify individuals at high risk of
individual cancers, but the effectiveness of PRS on overall cancer risk assessment and the …

Bioinformatic research relies on large-scale computational infrastructures which have a
nonzero carbon footprint but so far, no study has quantified the environmental costs of …

Background Genetic variation increases the risk of lung cancer, but the extent to which
smoking amplifies this effect remains unknown. Therefore, we aimed to investigate the risk of …

Since the publication of the first genome-wide association study for cancer in 2007,
thousands of common alleles that are associated with the risk of cancer have been …