TSPO protein binding partners in bacteria, animals, and plants
C Hiser, BL Montgomery, S Ferguson-Miller - Journal of Bioenergetics and …, 2021 - Springer
The ancient membrane protein TSPO is phylogenetically widespread from archaea and
bacteria to insects, vertebrates, plants, and fungi. TSPO's primary amino acid sequence is …
bacteria to insects, vertebrates, plants, and fungi. TSPO's primary amino acid sequence is …
Insight into the structural features of TSPO: implications for drug development
The translocator protein (TSPO), an 18-kDa transmembrane protein primarily found in the
outer mitochondrial membrane, is evolutionarily conserved and widely distributed across …
outer mitochondrial membrane, is evolutionarily conserved and widely distributed across …
Membrane-mediated ligand unbinding of the PK-11195 ligand from TSPO
The translocator protein (TSPO), previously known as the peripheral benzodiazepine
receptor, is of longstanding medical interest as both a biomarker for neuroinjury and a …
receptor, is of longstanding medical interest as both a biomarker for neuroinjury and a …
[HTML][HTML] Applications of water molecules for analysis of macromolecule properties
Water molecules maintain proteins' structures, functions, stabilities and dynamics. They can
occupy certain positions or pass quickly via a protein's interior. Regardless of their …
occupy certain positions or pass quickly via a protein's interior. Regardless of their …
[HTML][HTML] The mutual and dynamic role of TSPO and ligands in their binding process: an example with PK-11195
Translocator protein (TSPO) is an 18 kDa transmembrane protein, localized primarily on the
outer mitochondrial membrane. It has been found to be involved in various physiological …
outer mitochondrial membrane. It has been found to be involved in various physiological …
The mitochondrial translocator protein (TSPO, 18ákDa): A key multifunctional molecule in liver diseases
Translocator protein (TSPO, 18ákDa), previously known as peripheral-type benzodiazepine
receptor, is an evolutionarily conserved and tryptophan-rich 169-amino-acid protein located …
receptor, is an evolutionarily conserved and tryptophan-rich 169-amino-acid protein located …
[HTML][HTML] Structure-Based Drug Design for TSPO: Challenges and Opportunities
The translocator protein 18 kDa (TSPO) is an evolutionarily conserved mitochondrial
transmembrane protein implicated in various neuropathologies and inflammatory conditions …
transmembrane protein implicated in various neuropathologies and inflammatory conditions …
Versatile dimerisation process of translocator protein (TSPO) revealed by an extensive sampling based on a coarse-grained dynamics study
Translocator protein (TSPO), a mitochondrial membrane protein, has been extensively
studied, and its role is still debated and continues to be enigmatic. From a structural …
studied, and its role is still debated and continues to be enigmatic. From a structural …
Direct and specific binding of cholesterol to the mitochondrial translocator protein (TSPO) using PhotoClick cholesterol analogue
E Georges, C Sottas, Y Li… - The journal of …, 2021 - academic.oup.com
The translocator protein (TSPO) is a five-helix transmembrane protein localized to the outer
mitochondria membrane. Radioligand binding assays and chemical crosslinking showed …
mitochondria membrane. Radioligand binding assays and chemical crosslinking showed …
Characterization of the high-affinity drug ligand binding site of mouse recombinant TSPO
S Iatmanen-Harbi, L Senicourt… - International Journal of …, 2019 - mdpi.com
The optimization of translocator protein (TSPO) ligands for Positron Emission Tomography
as well as for the modulation of neurosteroids is a critical necessity for the development of …
as well as for the modulation of neurosteroids is a critical necessity for the development of …