Centromeres of Candida albicans form on unique and different DNA sequences but a
closely related species, Candida tropicalis, possesses homogenized inverted repeat (HIR) …

Genetic interactions impact both normal human physiology and human diseases, such as
cancer. Here, we study genetic interactions through the lens of human lung cancers driven …

Ever since single-cell sequencing (scDNA-seq) was coined 'method of the year'in 2013, it
has provided many insights into the evolution of tumors, viewed as a branching process of …

Background Hi-C and its variant techniques have been developed to capture the spatial
organization of chromatin. Normalization of Hi-C contact map is essential for accurate …

Molecular sequence analysis is vital for understanding the functions, structures, and
behaviors of organisms, including viruses, playing a key role in disease prevention and …

The utilization of extensive sequencing data is essential for exploration of computational
challenges, particularly resolving clustering problems and simulating single-cell tumor …

Aneuploidy is the gain or loss of chromosomes in a cell, has major effects in eukaryotes and
is linked to cancer and genetic diseases in humans. Aneuploidy is common in the wine …

Background: The revolution in next-generation sequencing (NGS) technology has allowed
easy access and sharing of high-throughput sequencing datasets of cancer cell lines and …

Next-generation sequencing (NGS) promises highresolution landscapes of cancer
genomes, especially the genomewide copy number alterations (CNAs). Detecting CNAs …

The purpose of this study was to investigate the relevance of subtelomeric cytogenomic
changes in patients with sporadic colorectal cancer (CRC) using multiplex ligation …