The heart is uniquely responsible for providing its own blood supply through the coronary
circulation. Regulation of coronary blood flow is quite complex and, after over 100 years of …

It is increasingly recognized that obesity is a risk factor for microvascular disease, involving
both structural and functional changes in the microvasculature. This review aims to describe …

This review is a historical account about purinergic signalling in the heart, for readers to see
how ideas and understanding have changed as new experimental results were published …

Adenosine is an ubiquitous extracellular signaling molecule and plays a fundamental role in
the regulation of coronary microcirculation through activation of adenosine receptors (ARs) …

Diabetes mellitus (DM) and hypertension are highly prevalent worldwide health problems
and frequently associated with severe clinical complications, such as diabetic …

Myocardial perfusion and coronary vascular resistance are regulated by signaling
metabolites released from the local myocardium that act either directly on the VSMC or …

Vascular dysfunction plays a pivotal role in the development of systemic complications
associated with arterial hypertension and diabetes. The endothelium, or more specifically …

Coronary microvascular dysfunction (CMD) has been proposed as an important component
of diabetes mellitus (DM)-and hypercholesterolemia-associated coronary artery disease …

Uridine adenosine tetraphosphate (Up 4 A), biosynthesized by activation of vascular
endothelial growth factor receptor (VEGFR) 2, was initially identified as a potent endothelium …

The dinucleotide uridine adenosine tetraphosphate (Up 4 A), which has both purine and
pyrimidine moieties, was reported as a novel endothelium-derived contracting factor …