The 1013–1014 microorganisms present in the human gut (collectively known as the human
gut microbiota) dedicate substantial percentages of their genomes to the degradation and …

The availability of host and dietary carbohydrates in the gastrointestinal (GI) tract plays a key
role in sha** the structure-function of the microbiota. In particular, some gut bacteria have …

Carbohydrate binding modules (CBMs) are independent non-catalytic domains widely found
in carbohydrate-active enzymes (CAZymes), and they play an essential role in the substrate …

Lysosomal storage diseases (LSDs) are a class of metabolic disorders caused by mutations
in proteins critical for lysosomal function. Such proteins include lysosomal enzymes …

The enzymatic hydrolysis of the glycosidic bond continues to gain importance, reflecting the
critically important roles complex glycans play in health and disease as well as the rekindled …

Lysosomal storage diseases (LSDs) are a group of genetic disorders due to defects in any
aspect of lysosomal biology. During the past two decades, different approaches have been …

O-linked N-acetyl-β-d-glucosamine (O-GlcNAc) is a ubiquitous and dynamic post-
translational modification known to modify over 3,000 nuclear, cytoplasmic, and …

The O-GlcNAc modification is found on many nucleocytoplasmic proteins. The dynamic
nature of O-GlcNAc, which in some ways is reminiscent of phosphorylation, has enabled …

The mucopolysaccharidosis (MPS) disorders are a group of lysosomal storage diseases
caused by lysosomal enzyme deficits that lead to glycosaminoglycan accumulation, affecting …

The O-GlcNAc post-translational modification is considered to act as a sensor of nutrient flux
through the hexosamine biosynthetic pathway. A cornerstone of this hypothesis is that global …