With the development and wide usage of CRISPR technology, the presence of R-loop
structures, which consist of an RNA: DNA hybrid and a displaced single strand (ss) DNA …

DDX3X syndrome is a neurodevelopmental disorder accounting for up to 3% of cases of
intellectual disability (ID) and affecting primarily females. Individuals diagnosed with DDX3X …

RNA helicase DHX9 is essential for genome stability by resolving aberrant R-loops.
However, its regulatory mechanisms remain unclear. Here we show that SUMOylation at …

Purpose FLVCR1 encodes a solute carrier protein implicated in heme, choline, and
ethanolamine transport. Although Flvcr1−/− mice exhibit skeletal malformations and …

Epigenetic dysregulation has emerged as an important etiological mechanism of
neurodevelopmental disorders (NDDs). Pathogenic variation in epigenetic regulators can …

Mitochondria are critical for brain development and homeostasis. Therefore, pathogenic
variation in the mitochondrial or nuclear genome which disrupts mitochondrial function …

The DEAD/DEAH-box family of RNA helicases (RHs) is among the most abundant and
conserved in eukaryotes. These proteins catalyze the remodeling of RNAs to regulate their …

Neurodevelopmental disorders (NDDs) represent a large group of disorders with an onset in
the neonatal or early childhood period; NDDs include intellectual disability (ID), autism …

Epilepsy and autism often co‐occur in genetic developmental and epileptic
encephalopathies (DEEs), but their underlying neurobiological processes remain poorly …

Mauritian-origin cynomolgus macaques (MCMs) serve as a powerful nonhuman primate
model in biomedical research due to their unique genetic homogeneity, which simplifies …