Cyclic dinucleotides (CDNs) are highly versatile signalling molecules that control various
important biological processes in bacteria. The best-studied example is cyclic di-GMP (c-di …

Twenty-five years have passed since the discovery of cyclic dimeric (3′→ 5′) GMP (cyclic
di-GMP or c-di-GMP). From the relative obscurity of an allosteric activator of a bacterial …

Signaling photoreceptors use the information contained in the absorption of a photon to
modulate biological activity in plants and a wide range of organisms. The fundamental—and …

Biofilm formation and biofilm-induced biodeterioration of surfaces have deeply affected the
life of our community. Cyclic dimeric guanosine monophosphate (c-di-GMP) is a small …

Sensory photoreceptors underpin light-dependent adaptations of organismal physiology,
development, and behavior in nature. Adapted for optogenetics, sensory photoreceptors …

For an organism to survive, it must be able to sense its environment and regulate
physiological processes accordingly. Understanding how bacteria integrate signals from …

Nucleotide signalling molecules contribute to the regulation of cellular pathways in all forms
of life. In recent years, the discovery of new signalling molecules in bacteria and archaea, as …

Abstract Bis-(3′-5′)-cyclic dimeric GMP (c-di-GMP) is a ubiquitous second messenger that
regulates cell surface-associated traits in bacteria. Components of this regulatory network …

Bacteria have a tendency to attach to surfaces and grow as structured communities called
biofilms. Chronic biofilm infections are a problem because they tend to resist antibiotic …

Cyclic di-GMP (c-di-GMP) synthetases and hydrolases (GGDEF, EAL, and HD-GYP
domains) can be readily identified in bacterial genome sequences by using standard …