Lipids are crucial components of cellular function owing to their role in membrane formation,
intercellular signaling, energy storage, and homeostasis maintenance. In the brain, lipid …

ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

An excess of saturated fatty acids and simple sugars in the diet is a known environmental
risk factor of Alzheimer's disease (AD) but the holistic view of the interacting processes …

Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …

Astrocytes, the most abundant glial cell type in the brain, are underrepresented in traditional
cortical organoid models due to the delayed onset of cortical gliogenesis. Here we introduce …

While the central nervous system compromises 2% of our body weight, it harbors up to 25%
of the body's cholesterol. Cholesterol levels in the brain are tightly regulated for …

Glioblastoma (GBM) is the most common type of adult malignant brain tumor, but its
molecular mechanisms are not well understood. In addition, the knowledge of the disease …

Brain is a vital organ of the human body which performs very important functions such as
analysis, processing, coordination, and execution of electrical signals. For this purpose, it …

Knowledge of lipid droplets (LDs) has evolved from simple depots of lipid storage to
dynamic and functionally active organelles involved in a variety of cellular functions. Studies …