Hypoxia is a major hallmark of the tumor microenvironment that is strictly associated with
rapid cancer progression and induction of metastasis. Hypoxia inhibits disulfide bond …

Cellular Ca 2+ homeostasis is maintained through the integrated and coordinated function
of Ca 2+ transport molecules, Ca 2+ buffers and sensors. These molecules are associated …

Recently, many studies have been conducted trying to explain the molecular mechanism of
curcumin action in various pathological states of the cell and the organism. Curcumin is …

Safety concerns have been raised over the extensive applications of silver nanoparticles
(AgNPs) because nano dimensions make them highly bioactive, being potentially harmful to …

Colorectal cancer (CRC) is among the top three cancer with higher incident and mortality
rate worldwide. It is estimated that about over than 1.1 million of death and 2.2 million new …

Cancer constitutes a grave problem nowadays in view of the fact that it has become one of
the main causes of death worldwide. Poor clinical prognosis is presumably due to cancer …

Calcium ions (Ca2+) play a complex role in orchestrating diverse cellular processes,
including cell death and survival. To trigger signaling cascades, intracellular Ca2+ is …

Curcumin, the bioactive polyphenolic ingredient of turmeric, has been extensively studied for
its effects on human papilloma virus (HPV) infection as well as primary and malignant …

The clinical challenge posed by p53 abnormalities in hematological malignancies requires
therapeutic strategies other than standard genotoxic chemotherapies. ONC201 is a first-in …

Inter-organellar communication often takes the form of Ca2+ signals. These Ca2+ signals
originate from the endoplasmic reticulum (ER) and regulate different cellular processes like …