The heart is the most metabolically active organ in the human body, and cardiac metabolism
has been studied for decades. However, the bulk of studies have focused on animal models …

Calcium is an important signaling molecule involved in the regulation of many cellular
functions. The large free energy in the Ca2+ ion membrane gradients makes Ca2+ signaling …

The writing committee consisted of acknowledged experts in the field of CMR, as well as a
liaison from the ACCF Task Force on Clinical ECDs, the oversight group for this document …

Cardiovascular magnetic resonance (CMR) is established in clinical practice for the
diagnosis and management of diseases of the cardiovascular system. However, current …

Background In patients with heart failure due to dilated cardiomyopathy, cardiac energy
metabolism is impaired, as indicated by a reduction of the myocardial phosphocreatine-to …

ContextThe mechanisms that drive progression from fatty liver to steatohepatitis and
cirrhosis are unknown. In animal models, obese mice with fatty livers are vulnerable to liver …

BACKGROUND The purpose of this work was to further define the value of cardiac 31P
magnetic resonance (MR) spectroscopy for patients with coronary artery disease and dilated …

The heart consumes more energy per gram than any other organ, and the creatine kinase
(CK) reaction serves as its prime energy reserve. Because chemical energy is required to …

RS Balaban. Cardiac Energy Metabolism Homeotasis: Role of Cytosolic Calcium. Journal of
Molecular and Cellular Cardiology (2002) 34, 1259–1271. The heart is capable of …

Background After hospitalization for chest pain, women are more likely than men to have
normal coronary angiograms. In such women, myocardial ischemia in the absence of …