In this 21 st century, Malaria remains a global burden and causes massive economic trouble
to disease-endemic nations. The control and eradication of malaria is a major challenge that …

Quinolines have become essential to many drugs, including broad-spectrum antibiotics,
antivirus, antitubercular, and antimalarial agents. Owing to their importance in medicinal and …

In response to the malaria parasite's resistance towards quinoline-based antimalarial drugs,
we have employed quinoline-containing compounds in combination with …

Post-translational modifications (PTMs) are essential for regulating protein functions,
influencing various fundamental processes in eukaryotes. These include, but are not limited …

Malaria is a very destructive and lethal parasitic disease that causes significant mortality
worldwide, resulting in the loss of millions of lives annually. It is an infectious disease …

Malaria still threatens half the globe population despite successful Artemisinin-based
combination therapy. One of the reasons for our inability to eradicate malaria is the …

Context Malaria remains a significant global health challenge with emerging resistance to
current treatments. Plasmodium falciparum glutathione reductase (Pf GR) plays a critical role …

Dihydropyrimidinones (DHPMs) are the most significant heterocyclic ring systems that have
sparked attention in medicinal chemistry because of their putative diverse biological actions …

Malaria and leishmaniasis are two vector-borne diseases (VBDs) caused by parasites
(Plasmodium and Leishmania respectively), transmitted to humans, by infected insects …

The Biginelli reaction is a cyclo-condensation process that is one-pot acid-catalyzed and
produces functionalized DHPMs by combining urea, β-keto ester, and aromatic aldehyde …