Neonatal sepsis remains a feared and serious complication, especially among very low birth
weight (VLBW) preterm infants. Neonatal sepsis is divided into early-onset and late-onset …

In this review, we examine the current status of S taphylococcus aureus vaccine
development and the prospects for future vaccines. Examination of the clinical trials to date …

Orthopaedic and trauma device-related infection (ODRI) remains one of the major
complications in modern trauma and orthopaedic surgery. Despite best practice in medical …

Staphylococcus aureus is both a commensal organism and also an important opportunistic
human pathogen, causing a variety of community and hospital-associated pathologies, such …

Neonates, particularly those born prematurely, are exquisitely vulnerable to life-threatening
infections. This increased susceptibility to infection is maintained into childhood. Despite the …

Staphylococcus aureus is a highly successful bacterial pathogen owing to its abundance of
cell surface and secreted virulence factors. It is estimated that 30% of the population is …

Bacterial sepsis in the neonate is a clinical syndrome characterized by systemic signs of
infection and accompanied by bacteremia in the first month of life. Meningitis in the neonate …

This review considers the reasons why the staphylococcal vaccine trials may have failed,
based on new information about protective immunity against Staphylococcus aureus. The …

While Staphylococcus aureus (S. aureus) bacteria are part of the human commensal flora,
opportunistic invasion following breach of the epithelial layers can lead to a wide array of …

Staphylococcus aureus is a significant cause of human infection. Here, we demonstrate that
mutations in the transcriptional repressor of purine biosynthesis, purR, enhance the …