Angiogenesis is an essential process in normal development and in adult physiology, but
can be disrupted in numerous diseases. The concept of targeting angiogenesis for treating …

Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …

Leakage from blood vessels into tissues is governed by mechanisms that control endothelial
barrier function to maintain homeostasis. Dysregulated endothelial permeability contributes …

Cell adhesion to the extracellular matrix is fundamental to tissue integrity and human health.
Integrins are the main cellular adhesion receptors that through multifaceted roles as …

The enhancement of wound healing has been a goal of medical practitioners for thousands
of years. The development of chronic, non-healing wounds is a persistent medical problem …

Angiopoietins 1–4 (Ang1–4) represent an important family of growth factors, whose activities
are mediated through the tyrosine kinase receptors, Tie1 and Tie2. The best characterized …

Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is presenting as a systemic disease associated with …

Purpose To evaluate the 2-year efficacy, durability, and safety of dual angiopoietin-2 and
vascular endothelial growth factor (VEGF) A pathway inhibition with intravitreal faricimab …

Cell adhesion to the extracellular matrix is fundamental to metazoan multicellularity and is
accomplished primarily through the integrin family of cell-surface receptors. Integrins are …

The endothelial angiopoietin (ANG)–TIE growth factor receptor pathway regulates vascular
permeability and pathological vascular remodelling during inflammation, tumour …