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Radiation-induced tumor immune microenvironments and potential targets for combination therapy
S Guo, Y Yao, Y Tang, Z ** adaptive immunity. DCs have a unique ability to sample their environment, capture …
Natural killer cell-related prognosis signature characterizes immune landscape and predicts prognosis of HNSCC
H Chi, X **e, Y Yan, G Peng, DF Strohmer… - Frontiers in …, 2022 - frontiersin.org
Background Head and neck squamous cell carcinoma (HNSCC), the most common head
and neck cancer, is highly aggressive and heterogeneous, resulting in variable prognoses …
and neck cancer, is highly aggressive and heterogeneous, resulting in variable prognoses …
Targeting oral tumor microenvironment for effective therapy
Oral cancers are among the common head and neck malignancies. Different anticancer
therapy modalities such as chemotherapy, immunotherapy, radiation therapy, and also …
therapy modalities such as chemotherapy, immunotherapy, radiation therapy, and also …
Selective targeting of IL2Rβγ combined with radiotherapy triggers CD8-and NK-mediated immunity, abrogating metastasis in HNSCC
J Gadwa, M Amann, TE Bickett, MW Knitz… - Cell Reports …, 2023 - cell.com
The implementation of cancer immunotherapies has seen limited clinical success in head
and neck squamous cell carcinoma (HNSCC). Interleukin-2 (IL-2), which modulates the …
and neck squamous cell carcinoma (HNSCC). Interleukin-2 (IL-2), which modulates the …
The mouse oral carcinoma (MOC) model: a 10-year retrospective on model development and head and neck cancer investigations
Preclinical models of cancer have long been paramount to understanding tumor
development and advancing the treatment of cancer. Creating preclinical models that mimic …
development and advancing the treatment of cancer. Creating preclinical models that mimic …
When DNA damage responses meet tumor immunity: From mechanism to therapeutic opportunity
DNA damage is a prevalent phenomenon in the context of cancer progression. Evidence
suggests that DNA damage responses (DDR) are pivotal in overcoming tumor immune …
suggests that DNA damage responses (DDR) are pivotal in overcoming tumor immune …
Natural killer cell-related prognostic risk model predicts prognosis and treatment outcomes in triple-negative breast cancer
Z Liu, M Ding, P Qiu, K Pan, Q Guo - Frontiers in Immunology, 2023 - frontiersin.org
Background Natural killer (NK) cells are crucial to the emergence, identification, and
prognosis of cancers. The roles of NK cell-related genes in the tumor immune …
prognosis of cancers. The roles of NK cell-related genes in the tumor immune …
Altered extracellular matrix correlates with an immunosuppressive tumor microenvironment and disease progression in younger adults with oral cavity squamous cell …
Introduction Oral cavity squamous cell carcinoma (OSCC) occurs most frequently in
patients> 60 years old with a history of tobacco and alcohol use. Epidemiological studies …
patients> 60 years old with a history of tobacco and alcohol use. Epidemiological studies …
High FLT3 expression increases immune‐cell infiltration in the tumor microenvironment and correlates with prolonged disease‐free survival in patients with non …
Most of the currently used cancer immunotherapies inhibit the programmed cell death
protein 1 (PD1)–programmed cell death 1 ligand 1 (PDL1) axis of T‐cells. However …
protein 1 (PD1)–programmed cell death 1 ligand 1 (PDL1) axis of T‐cells. However …