TGF-β in radiotherapy: Mechanisms of tumor resistance and normal tissues injury

B Farhood, M Hoseini-Ghahfarokhi, E Motevaseli… - Pharmacological …, 2020 - Elsevier
Emerging evidences show that changes in tumor stroma can adapt cancer cells to
radiotherapy, thereby leading to a reduction in tumor response to treatment. On the other …

Radiation‐induced myocardial fibrosis: mechanisms underlying its pathogenesis and therapeutic strategies

B Wang, H Wang, M Zhang, R Ji, J Wei… - Journal of Cellular …, 2020 - Wiley Online Library
Radiation‐induced myocardial fibrosis (RIMF) is a potentially lethal clinical complication of
chest radiotherapy (RT) and a final stage of radiation‐induced heart disease (RIHD). RIMF is …

COX-2 in liver fibrosis

H Yang, Y Xuefeng, W Shandong, X Jianhua - Clinica chimica acta, 2020 - Elsevier
As a vital inducible sensor, cyclooxygenase-2 (COX-2) plays an important role in the
progress of hepatic fibrogenesis. Activation of hepatic stellate cells (HSCs) in the liver can …

Paracrine effects of human amniotic epithelial cells protect against chemotherapy-induced ovarian damage

Q Zhang, S Bu, J Sun, M Xu, X Yao, K He… - Stem cell research & …, 2017 - Springer
Background Human amniotic epithelial cells (hAECs) are attractive candidates for
regenerative medical therapy, with the potential to replace deficient cells and improve …

Inflammatory mediators in oral cancer: pathogenic mechanisms and diagnostic potential

SE Niklander - Frontiers in Oral Health, 2021 - frontiersin.org
Approximately 15% of cancers are attributable to the inflammatory process, and growing
evidence supports an association between oral squamous cell carcinoma (OSCC) and …

TGF-β1 induces VEGF expression in human granulosa-lutein cells: a potential mechanism for the pathogenesis of ovarian hyperstimulation syndrome

L Fang, Y Li, S Wang, Y Li, HM Chang, Y Yi… - … & molecular medicine, 2020 - nature.com
Ovarian hyperstimulation syndrome (OHSS) is one of the most serious and iatrogenic
complications that can occur during in vitro fertilization treatment. Although the pathogenesis …

Transforming growth factor-β is involved in maintaining oocyte meiotic arrest by promoting natriuretic peptide type C expression in mouse granulosa cells

J Yang, Y Zhang, X Xu, J Li, F Yuan, S Bo, J Qiao… - Cell Death & …, 2019 - nature.com
Natriuretic peptide type C (NPPC) secreted by mural granulosa cells (MGCs) maintains
oocyte meiotic arrest via the activation of guanylyl cyclase-linked natriuretic peptide receptor …

Canine placenta: a source of prepartal prostaglandins during normal and antiprogestin-induced parturition

MP Kowalewski, HB Beceriklisoy, C Pfarrer… - …, 2010 - rep.bioscientifica.com
Expression of cyclooxygenase 2 (COX2, now known as PTGS2), prostaglandin E2 synthase
(PTGES, PGES), and prostaglandin F2α synthase (PGFS), of the respective receptors …

Role of transforming growth factor-β in muscle damage and regeneration: focused on eccentric muscle contraction

J Kim, J Lee - Journal of exercise rehabilitation, 2017 - pmc.ncbi.nlm.nih.gov
High-intensity eccentric muscle contraction induces muscle damage. Damaged muscles
recover through different processes, including degeneration, inflammation, regeneration …

TGF-β1 downregulates StAR expression and decreases progesterone production through Smad3 and ERK1/2 signaling pathways in human granulosa cells

L Fang, HM Chang, JC Cheng… - The Journal of …, 2014 - academic.oup.com
Context: Regulation of progesterone production in granulosa cells is important for normal
reproductive functions. Steroidogenic acute regulatory protein (StAR) is recognized as the …