The diversity, modularity, and efficacy of CRISPR-Cas systems are driving a
biotechnological revolution. RNA-guided Cas enzymes have been adopted as tools to …

CRISPR (clustered regularly interspaced short palindromic repeats)/Cas (CRISPR-
associated) proteins are powerful gene-editing tools because of their ability to accurately …

The 3D organization of chromatin regulates many genome functions. Our understanding of
3D genome organization requires tools to directly visualize chromatin conformation in its …

Nucleic acid molecules possess many superior properties, including high designability and
structural predictability, making them attractive biosensing and bioimaging tools. The …

The emergence of antibiotic-resistant bacterial strains is a source of public health concern
across the globe. As the discovery of new conventional antibiotics has stalled significantly …

Mutations in mitochondrial DNA (mtDNA) play critical roles in many human diseases. In vivo
visualization of cells bearing mtDNA mutations is important for resolving the complexity of …

Liver disease, particularly viral hepatitis and hepatocellular carcinoma (HCC), is a global
healthcare burden and leads to more than 2 million deaths per year worldwide. Despite …

Nucleic acids, with the advantages of programmability and biocompatibility, have been
widely used to design different kinds of novel biocomputing devices. Recently, nucleic acid …

The discovery and characterization of the prokaryotic CRISPR-Cas immune system has led
to a revolution in genome editing and engineering technologies. Despite the fact that most …

The CRISPR/Cas technology, derived from an adaptive immune system in bacteria, has
been awarded the Nobel Prize in Chemistry in 2020 for its success in gene editing …