With the advent of X-ray free-electron lasers (XFELs), new, high-throughput serial
crystallography techniques for macromolecular structure determination have emerged …

Highlights•Common data quality indicators grouped as primary, secondary, or
wrong/misleading.•A gedanken experiment reveals shortcomings of some common …

INTRODUCTION Molecularly targeted drugs such as imatinib and crizotinib have
revolutionized the treatment of certain blood and lung cancers because of their remarkable …

Chemokines and their G-protein-coupled receptors play a diverse role in immune defence
by controlling the migration, activation and survival of immune cells. They are also involved …

Flaviviruses, the human pathogens responsible for dengue fever, West Nile fever, tick-borne
encephalitis, and yellow fever, are endemic in tropical and temperate parts of the world. The …

Cpf1 is an RNA-guided endonuclease that is emerging as a powerful genome-editing tool,.
Here we provide insight into its DNA-targeting mechanism by determining the structure of …

Monday, February 19, 2018 303a neuronal excitability, respond to lipids, temperature and
mechanical stretch, and influence pain, temperature perception and anaesthetic responses …

Abstract Glucagon-like peptide 1 (GLP-1) regulates glucose homeostasis through the control
of insulin release from the pancreas. GLP-1 peptide agonists are efficacious drugs for the …

XDSGUI is a lightweight graphical user interface (GUI) for the XDS, SHELX and
ARCIMBOLDO program packages that serves both novice and experienced users in …

Intracellular signaling during oxidative stress is complex, with organelle-to-nucleus
retrograde communication pathways ill-defined or incomplete. Here we identify the 3 …