Small-molecule drug discovery in triple negative breast cancer: current situation and future directions
M Liao, J Zhang, G Wang, L Wang, J Liu… - Journal of medicinal …, 2021 - ACS Publications
Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, but
an effective targeted therapy has not been well-established so far. Considering the lack of …
an effective targeted therapy has not been well-established so far. Considering the lack of …
The dynamic role of platelets in cancer progression and their therapeutic implications
S Li, Z Lu, S Wu, T Chu, B Li, F Qi, Y Zhao… - Nature Reviews Cancer, 2024 - nature.com
Systemic antiplatelet treatment represents a promising option to improve the therapeutic
outcomes and therapeutic efficacy of chemotherapy and immunotherapy due to the critical …
outcomes and therapeutic efficacy of chemotherapy and immunotherapy due to the critical …
Tumor microenvironment: key players in triple negative breast cancer immunomodulation
Simple Summary The tumor microenvironment (TME) is a complicated network composed of
various cells, signaling molecules, and extra cellular matrix. TME plays a crucial role in triple …
various cells, signaling molecules, and extra cellular matrix. TME plays a crucial role in triple …
Penetrable nanoplatform for “cold” tumor immune microenvironment reeducation
Q Chen, Y He, Y Wang, C Li, Y Zhang, Q Guo… - Advanced …, 2020 - Wiley Online Library
Lack of tumor‐infiltration lymphocytes (TILs) and resistances by overexpressed
immunosuppressive cells (principally, myeloid‐derived suppressor cells (MDSCs)) in tumor …
immunosuppressive cells (principally, myeloid‐derived suppressor cells (MDSCs)) in tumor …
Tumor-infiltrating CD8+ T cell antitumor efficacy and exhaustion: molecular insights
Highlights•Current cancer therapy targets both the tumor and the immune system.•Tumor
microenvironment (TME) regulates the anti-tumor immune responses.•Tumor-infiltrating …
microenvironment (TME) regulates the anti-tumor immune responses.•Tumor-infiltrating …
Copper chelation suppresses epithelial-mesenchymal transition by inhibition of canonical and non-canonical TGF-β signaling pathways in cancer
Background Metastatic cancer cells exploit Epithelial-mesenchymal-transition (EMT) to
enhance their migration, invasion, and resistance to treatments. Recent studies highlight that …
enhance their migration, invasion, and resistance to treatments. Recent studies highlight that …
[HTML][HTML] Diallyl disulfide and diallyl trisulfide in garlic as novel therapeutic agents to overcome drug resistance in breast cancer
Breast cancer is one of the leading causes of cancer-related deaths in women worldwide. It
is a cancer that originates from the mammary ducts and involves mutations in multiple …
is a cancer that originates from the mammary ducts and involves mutations in multiple …
CX-5461 enhances the efficacy of APR-246 via induction of DNA damage and replication stress in triple-negative breast cancer
A Makhale, D Nanayakkara, P Raninga… - International Journal of …, 2021 - mdpi.com
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer lacking
targeted therapy. Here, we evaluated the anti-cancer activity of APR-246, a P53 activator …
targeted therapy. Here, we evaluated the anti-cancer activity of APR-246, a P53 activator …
Cep55 overexpression promotes genomic instability and tumorigenesis in mice
High expression of centrosomal protein CEP55 has been correlated with clinico-
pathological parameters across multiple human cancers. Despite significant in vitro studies …
pathological parameters across multiple human cancers. Despite significant in vitro studies …
[HTML][HTML] 'Off-the-shelf'allogeneic antigen-specific adoptive T-cell therapy for the treatment of multiple EBV-associated malignancies
Background Epstein-Barr virus (EBV), an oncogenic human gammaherpesvirus, is
associated with a wide range of human malignancies of epithelial and B-cell origin. Recent …
associated with a wide range of human malignancies of epithelial and B-cell origin. Recent …