Conopeptides are a diverse group of recently evolved venom peptides used for prey capture
and/or defense. Each species of cone snails produces in excess of 1000 conopeptides, with …

Peptide therapeutics are acclaimed as a promising addition to the pharmaceutical arena,
and they continue to attract interest due to their high potency, bioavailability, and fewer …

Opioids are first-line drugs for moderate to severe acute pain and cancer pain. However,
these medications are associated with severe side effects, and whether they are efficacious …

Converging research efforts suggest that nicotine and other drugs that act at nicotinic
acetylcholine receptors (nAChRs) may be beneficial in the management of Parkinson's …

Marine snails of the genus Conus are a large family of predatory gastropods with an
unparalleled molecular diversity of pharmacologically active compounds in their venom …

Parkinson's disease is a debilitating movement disorder characterized by a generalized
dysfunction of the nervous system, with a particularly prominent decline in the nigrostriatal …

Techniques for measuring efferent effects using otoacoustic emissions are now well
developed and have promise in clinical applications ranging from predicting which patients …

Snake venom three-finger α-neurotoxins (α-3FNTx) act on postsynaptic nicotinic
acetylcholine receptors (nAChRs) at the neuromuscular junction (NMJ) to produce skeletal …

Acetylcholine (ACh) is not only a neurotransmitter but is an ancient molecule that can be
released by and act on non-neuronal cells. In these cells the system of ACh-synthesizing …

Nicotinic acetylcholine receptors (nAChRs) are master regulators of immune functions via
the cholinergic anti-inflammatory pathway and are expressed in microglia, the brain's …