Drug discovery has traditionally focused on using libraries of small molecules to identify
therapeutic drugs, but new modalities, especially libraries of genetically encoded cyclic …

In ageing populations, neurodegenerative diseases increase in prevalence, exacting an
enormous toll on individuals and their communities. Multiple complementary experimental …

Inteins are auto-processing domains found in organisms from all domains of life. These
proteins carry out a process known as protein splicing, which is a multi-step biochemical …

Macrocyclic peptides are an emerging class of therapeutics that can modulate protein–
protein interactions. In contrast to the heavily automated high-throughput screening systems …

Highlights•SICLOPPS allows the rapid generation of cyclic peptide libraries in cells.•A
variety of cyclic peptide ring sizes may be generated with SICLOPPS.•SICLOPPS libraries …

To date, small molecules and macromolecules, including antibodies, have been the most
pursued substances in drug screening and development efforts. Despite numerous …

The cyclisation of polypeptides can play a crucial role in exerting biological functions,
maintaining stability under harsh conditions and conferring proteolytic resistance, as …

The biotech industry relies on cell factories for production of pharmaceutical proteins, of
which several are among the top-selling medicines. There is, therefore, considerable …

SUMMARY α-Synuclein (α-syn) is a small lipid-binding protein involved in vesicle trafficking
whose function is poorly characterized. It is of great interest to human biology and medicine …

Peptides and their mimetics are increasingly recognised as drug-like molecules, particularly
for intracellular protein-protein interactions too large for inhibition by small molecules, and …