Cells respond to protein-damaging (proteotoxic) stress by activation of the Heat Shock
Response (HSR). The HSR provides cells with an enhanced ability to endure proteotoxic …

The major classes of molecular chaperones have highly variable sequences, sizes, and
shapes, yet they all bind to unfolded proteins, limit their aggregation, and assist in their …

Abstract Systems-level assessments of protein-protein interaction (PPI) network dysfunctions
are currently out-of-reach because approaches enabling proteome-wide identification …

Genetic variation in human populations can result in the misfolding and aggregation of
proteins, giving rise to systemic and neurodegenerative diseases that require management …

Assuring a healthy proteome is indispensable for survival and organismal health. Proteome
disbalance and the loss of the proteostasis buffer are hallmarks of various diseases. The …

Optimal functioning of neuronal networks is critical to the complex cognitive processes of
memory and executive function that deteriorate in Alzheimer's disease (AD). Here we use …

Diseases are a manifestation of how thousands of proteins interact. In several diseases,
such as cancer and Alzheimer's disease, proteome-wide disturbances in protein-protein …

Adaptation to acute and chronic stress and/or persistent stressors is a subject of wide
interest in central nervous system disorders. In this context, stress is an effector of change in …

Tumor recurrence is a paradoxical function of a machinery, whereby a small proportion of
the cancer cell population enters a resistant, dormant state, persists long-term in this …

Alterations in protein-protein interaction networks are at the core of malignant transformation
but have yet to be translated into appropriate diagnostic tools. We make use of the kinetic …