Genetics of circadian rhythms and sleep in human health and disease
Circadian rhythms and sleep are fundamental biological processes integral to human
health. Their disruption is associated with detrimental physiological consequences …
health. Their disruption is associated with detrimental physiological consequences …
Genomics of circadian rhythms in health and disease
Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral
processes. The central circadian clock exerts control over myriad aspects of mammalian …
processes. The central circadian clock exerts control over myriad aspects of mammalian …
Association of sleep duration in middle and old age with incidence of dementia
Sleep dysregulation is a feature of dementia but it remains unclear whether sleep duration
prior to old age is associated with dementia incidence. Using data from 7959 participants of …
prior to old age is associated with dementia incidence. Using data from 7959 participants of …
Using human genetics to understand the disease impacts of testosterone in men and women
Testosterone supplementation is commonly used for its effects on sexual function, bone
health and body composition, yet its effects on disease outcomes are unknown. To better …
health and body composition, yet its effects on disease outcomes are unknown. To better …
GGIR: a research community–driven open source R package for generating physical activity and sleep outcomes from multi-day raw accelerometer data
Recent technological advances have transformed the research on physical activity initially
based on questionnaire data to the most recent objective data from accelerometers. The shift …
based on questionnaire data to the most recent objective data from accelerometers. The shift …
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors,
and has been reproducibly associated with future cardio-metabolic health outcomes. In …
and has been reproducibly associated with future cardio-metabolic health outcomes. In …
Sleep timing, chronotype and social jetlag: impact on cognitive abilities and psychiatric disorders
J Taillard, P Sagaspe, P Philip, S Bioulac - Biochemical pharmacology, 2021 - Elsevier
Sleep timing is controlled by the subtle interplay between circadian and homeostatic
oscillators which, according to their endogenous properties, allow beings to feel …
oscillators which, according to their endogenous properties, allow beings to feel …
[HTML][HTML] Trans effects on gene expression can drive omnigenic inheritance
Early genome-wide association studies (GWASs) led to the surprising discovery that, for
typical complex traits, most of the heritability is due to huge numbers of common variants …
typical complex traits, most of the heritability is due to huge numbers of common variants …
Circadian rhythm sleep–wake disturbances and depression in young people: implications for prevention and early intervention
A rate-limiting step in the prevention and early intervention of depressive disorders in young
people is our insufficient understanding of causal mechanisms. One plausible …
people is our insufficient understanding of causal mechanisms. One plausible …
Seasonality of brain function: role in psychiatric disorders
R Zhang, ND Volkow - Translational Psychiatry, 2023 - nature.com
Seasonality patterns are reported in various psychiatric disorders. The current paper
summarizes findings on brain adaptations associated with seasonal changes, factors that …
summarizes findings on brain adaptations associated with seasonal changes, factors that …